TACE联合放射性125I粒子及槐耳颗粒治疗中晚期肝癌的临床研究(1)

http://www.100md.com 2018年2月25日 《中国医学创新》 2018年第6期

     【摘要】 目的：探討分析经导管动脉化学栓塞(TACE)联合放射性125I粒子及槐耳颗粒治疗中晚期肝癌的效果。方法：选取番禺区中心医院收治的中晚期肝癌患者80例，按照随机数字表法分为观察组和对照组，各40例。对照组给予TACE联合放射性125I粒子治疗，观察组在对照组基础上给予槐耳颗粒治疗。比较两组近期临床疗效，治疗后1周AFP变化，随访6、12、18、24个月的生存率及不良反应。结果：观察组近期临床疗效缓解率为95.00%，高于对照组的72.50%(P<0.05)；治疗后1周，观察组AFP变化优于对照组，差异有统计学意义(P<0.05)；观察组随访6、12、18、24个月的生存率均高于对照组(P<0.05)；观察组不良反应发生率为10.00%，低于对照组的12.50%，但比较差异无统计学意义(P>0.05)。结论：TACE联合放射性125I粒子及槐耳颗粒治疗中晚期肝癌可提高近期临床疗效，延长患者的生存期，并且提高其生命质量，值得在临床上广泛推广。

    【关键词】 经导管动脉化学栓塞； 放射性125I粒子； 槐耳颗粒； 中晚期肝癌
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    Clinical Study of TACE Combined with Radioactive 125I Particles and Huaier Granule in Treatment of Middle and Advanced Liver Cancer/HE Chaoxiong，FENG Huigang，WENG Yu.//Medical Innovation of China，2018，15(06)：013-016

    【Abstract】 Objective：To investigate and andyze the transcatheter arterial chemoembolization(TACE) combined with radioactive 125I particles and Huaier Granule in treatment of middle and advanced liver cancer.Method：A total of 80 patients with middle and advanced liver cancer in Panyu District Central Hospital were selected，according to the random number table method，they were divided into observation group and control group，40 cases in each group.The control group was treated with TACE combined with radioactive 125I particles treatment，and observation group was treated with Huaier Granule on the basis of control group.The short term clinical effect，change of AFP at 1 week after treatment，survival rate and adverse reaction between two groups were compared.Result：The short term clinical efficacy of observation group was 95.00%，which was higher than 72.50% of control group(P<0.05).After treatment 1 week，the change of AFP in observation group was better than that of control group， the difference was statistically significant(P<0.05).The survival rate of 6，12，18 and 24 months in observation group was higher than that of control group(P<0.05).The incidence of adverse reactions in observation group was 10.00%，which was lower than 12.50% of control group，but the difference was not statistically significant(P>0.05).Conclusion：TACE combined with radioactive 125I particles and Huaier Granules in treatment of middle and advanced liver cancer can improve the short term clinical curative effect，prolong the survival period of patients and improve the quality of life，which is worth to be widely popularized clinically.

    【Key words】 Transcatheter arterial chemoembolization； Radioactive 125I particles； Huaier Granule；Middle and advanced liver cancer

    First-author’s address：Shawan People’s Hospital of Panyu District in Guangzhou，Guangzhou 511400，China, 百拇医药(何超雄 冯惠岗 翁裕)

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