还原型谷胱甘肽对异甘草酸镁治疗酒精性肝炎疗效的影响(1)
【摘要】 目的：研究還原型谷胱甘肽对异甘草酸镁治疗酒精性肝炎效果的影响。方法：选取2015年5月-2017年4月本院收治的酒精性肝炎患者120例。按照随机数字表法将其分为试验组和对照组，各60例。对照组采用异甘草酸镁注射液治疗，试验组采用异甘草酸镁注射液联合还原型谷胱甘肽注射液治疗，两组均以4周为一个疗程。比较两组治疗前后总胆红素(TBIL)含量、谷氨酰转肽酶(GGT)、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)等肝功能指标变化情况、肝脏B超检查结果及不良反应发生情况。结果：治疗后，两组ALT、AST、GGT、TBIL均低于治疗前，且试验组均低于对照组，比较差异均有统计学意义(P<0.05)；治疗后，两组血流信号减少、管道结构显示不清、肝脏远扬回声减弱及肝肿大的发生比例均低于治疗前，且试验组均低于对照组，比较差异均有统计学意义(P<0.05)；试验组总有效率为95.00%，高于对照组的81.67%，比较差异有统计学意义( 字2=5.175，P=0.023)；试验组不良反应发生率为8.3%，低于对照组的10.0%，但比较差异无统计学意义(P>0.05)。结论：还原型谷胱甘肽能够提高异甘草酸镁治疗酒精性肝炎的效果。
【关键词】 还原型谷胱甘肽； 异甘草酸镁； 酒精性肝炎
Effect of Reduced Glutathione on the Efficacy of Magnesium Isoglycyrrhizinate in Treatment of Alcoholic Hepatitis/DENG Ganlin，CHEN Lifen，ZHU Shujun，et al.//Medical Innovation of China，2018，15(06)：024-027
【Abstract】 Objective：To study the effect of Reduced Glutathione on the efficacy of Magnesium Isoglycyrrhizinate in treatment of alcoholic hepatitis.Method：A total of 120 patients with alcoholic hepatitis treated in our hospital from May 2015 to April 2017 were selected.According to the random number table method，they were divided into experimental group and control group，60 cases in each group.The control group was treated with Magnesium Isoglycyrrhizinate Injection，and experimental group was treated by Magnesium Isoglycyrrhizinate Injection combined with Reduced Glutathione Injection，they were treated for 4 weeks.The liver B-ultrasound resultsand and liver function indexes included total bilirubin(TBIL)，glutamyl transferase(GGT)，aspartate aminotransferase(AST) and alanine aminotransferase(ALT) before and after treatment in two groups were compared，and the occurrence of adverse reactions in two groups was compared.Result：After treatment，the ALT，AST，GGT and TBIL in experimental group were lower than those of control group，and experimental group were all lower than those of control group，the differences were statistically significant(P<0.05).After treatment，the incidence in reduction of blood flow signal，unclear structure of the conduit，low echo of the liver and hepatomegaly between two groups were lower than those of before treatment，and experimental group were lower than those of control group，the differences were statistically significant(P<0.05).The total effective rate of experimental group was 95.00%，which was higher than 81.67% of control group，the difference was statistically significant( 字2=5.175，P=0.023).The incidence of adverse reactions in experimental group was 8.3%，which was lower than 10.0% of control group，but the difference was not statistically significant(P>0.05).Conclusion：Reduced Glutathione can improve the effect of Magnesium Isoglycyrrhizinate in treatment of alcoholic hepatitis., 百拇医药(邓淦林 陈丽芬 朱淑军 刘鑫杰 邓少琦)
【关键词】 还原型谷胱甘肽； 异甘草酸镁； 酒精性肝炎
Effect of Reduced Glutathione on the Efficacy of Magnesium Isoglycyrrhizinate in Treatment of Alcoholic Hepatitis/DENG Ganlin，CHEN Lifen，ZHU Shujun，et al.//Medical Innovation of China，2018，15(06)：024-027
【Abstract】 Objective：To study the effect of Reduced Glutathione on the efficacy of Magnesium Isoglycyrrhizinate in treatment of alcoholic hepatitis.Method：A total of 120 patients with alcoholic hepatitis treated in our hospital from May 2015 to April 2017 were selected.According to the random number table method，they were divided into experimental group and control group，60 cases in each group.The control group was treated with Magnesium Isoglycyrrhizinate Injection，and experimental group was treated by Magnesium Isoglycyrrhizinate Injection combined with Reduced Glutathione Injection，they were treated for 4 weeks.The liver B-ultrasound resultsand and liver function indexes included total bilirubin(TBIL)，glutamyl transferase(GGT)，aspartate aminotransferase(AST) and alanine aminotransferase(ALT) before and after treatment in two groups were compared，and the occurrence of adverse reactions in two groups was compared.Result：After treatment，the ALT，AST，GGT and TBIL in experimental group were lower than those of control group，and experimental group were all lower than those of control group，the differences were statistically significant(P<0.05).After treatment，the incidence in reduction of blood flow signal，unclear structure of the conduit，low echo of the liver and hepatomegaly between two groups were lower than those of before treatment，and experimental group were lower than those of control group，the differences were statistically significant(P<0.05).The total effective rate of experimental group was 95.00%，which was higher than 81.67% of control group，the difference was statistically significant( 字2=5.175，P=0.023).The incidence of adverse reactions in experimental group was 8.3%，which was lower than 10.0% of control group，but the difference was not statistically significant(P>0.05).Conclusion：Reduced Glutathione can improve the effect of Magnesium Isoglycyrrhizinate in treatment of alcoholic hepatitis., 百拇医药(邓淦林 陈丽芬 朱淑军 刘鑫杰 邓少琦)
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