受胆固醇调节的变异剪接体及其意义(4)
[14] Yu C Y，Theusch E，Lo K，et al.HNRNPA1 regulates HMGCR alternative splicing and modulates cellular cholesterol metabolism[J].Human Molecular Genetics，2014，23(2)：319.
[15] Podlaha O，De S，Gonen M，et al.Histone Modifications Are Associated with Transcript Isoform Diversity in Normal and Cancer Cells[J].PLoS Computational Biology，2014，10(6)：e1003611.
[16] Sharma A，Nguyen H，Geng C，et al.Calcium-mediated histone modifications regulate alternative splicing in cardiomyocytes[J].Proceedings of the National Academy of Sciences of the United States of America，2014，111(46)：4920-4928.
[17] Llorian M，Schwartz S，Clark T A，et al.Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB[J].Nature Structural & Molecular Biology，2010，17(9)：1114.
[18] Luco R F，Allo M，Schor I E，et al.Epigenetics in alternative pre-mRNA splicing[J].Cell，2011，144(1)：16-26.
[19] Gooding C，Edge C，Lorenz M，et al.MBNL1 and PTB cooperate to repress splicing of Tpm1 exon 3[J].Nucleic Acids Research，2013，41(9)：4765-4782.
[20] Mickleburgh I，Kafasla P，Cherny D，et al.The organization of RNA contacts by PTB for regulation of FAS splicing[J].Nucleic Acids Research，2014，42(13)：8605-8620.
[21] Wagner E J，Garcia-Blanco M A.Polypyrimidine tract binding protein antagonizes exon definition[J].Molecular & Cellular Biology，2001，21(10)：3281.
[22] Medina M W，Gao F，Naidoo D，et al.Coordinately Regulated Alternative Splicing of Genes Involved in Cholesterol Biosynthesis and Uptake[J].PLoS One，2011，6(4)：e19420.
[23]趙金璇，王芳，徐峥嵘，等，表观遗传调控pre-mRNA的选择性剪接[J].遗传，2014，36(3)：248-255.
[24] Luco R F，Pan Q，Tominaga K，et al.Regulation of Alternative Splicing by Histone Modifications[J].Science，2010，327(5968)：996-1000.
(收稿日期：2017-12-22) (本文编辑：程旭然), 百拇医药(庞亚娜 赵晋枫 董元坤)
[15] Podlaha O，De S，Gonen M，et al.Histone Modifications Are Associated with Transcript Isoform Diversity in Normal and Cancer Cells[J].PLoS Computational Biology，2014，10(6)：e1003611.
[16] Sharma A，Nguyen H，Geng C，et al.Calcium-mediated histone modifications regulate alternative splicing in cardiomyocytes[J].Proceedings of the National Academy of Sciences of the United States of America，2014，111(46)：4920-4928.
[17] Llorian M，Schwartz S，Clark T A，et al.Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB[J].Nature Structural & Molecular Biology，2010，17(9)：1114.
[18] Luco R F，Allo M，Schor I E，et al.Epigenetics in alternative pre-mRNA splicing[J].Cell，2011，144(1)：16-26.
[19] Gooding C，Edge C，Lorenz M，et al.MBNL1 and PTB cooperate to repress splicing of Tpm1 exon 3[J].Nucleic Acids Research，2013，41(9)：4765-4782.
[20] Mickleburgh I，Kafasla P，Cherny D，et al.The organization of RNA contacts by PTB for regulation of FAS splicing[J].Nucleic Acids Research，2014，42(13)：8605-8620.
[21] Wagner E J，Garcia-Blanco M A.Polypyrimidine tract binding protein antagonizes exon definition[J].Molecular & Cellular Biology，2001，21(10)：3281.
[22] Medina M W，Gao F，Naidoo D，et al.Coordinately Regulated Alternative Splicing of Genes Involved in Cholesterol Biosynthesis and Uptake[J].PLoS One，2011，6(4)：e19420.
[23]趙金璇，王芳，徐峥嵘，等，表观遗传调控pre-mRNA的选择性剪接[J].遗传，2014，36(3)：248-255.
[24] Luco R F，Pan Q，Tominaga K，et al.Regulation of Alternative Splicing by Histone Modifications[J].Science，2010，327(5968)：996-1000.
(收稿日期：2017-12-22) (本文编辑：程旭然), 百拇医药(庞亚娜 赵晋枫 董元坤)
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