中老年少肌症与非酒精性脂肪肝的关联研究(4)
NAFLD發病机制主要是肝脏脂肪代谢异常、线粒体功能障碍和氧化应激，遗传变异和代谢改变及细胞损伤的易感性等相关。少肌症的机制研究目前很多，但机制并不明晰，包括内分泌失调、线粒体功能紊乱、运动神经元退化、氧化应激等、慢性炎症、异常脂肪积累等方面。两者均有脂肪异常，且骨骼肌分泌的肌肉因子可影响脂肪因子如脂联素的分泌，这可能是两者之间的共同机制，有待下一步研究。本研究的局限性在于没有肝脏活检，但瞬时成像技术的无创性及便捷性较广大人群接受，且均通过B超及CT检查来核对，诊断明确。另外LSM>9.6 kPa则有较大把握诊断进展期肝纤维化。同时本研究病例较少，近期仍在加大样本量，后期将会有报道。
综上所述，中老年原发性少肌症与NAFLD具有独立线性负相关。
参考文献
[1] Tovo C V，Fernandes S A，Buss C，et al.Sarcopenia and non-alcoholic fatty liver disease：Is there a relationship？ A systematic review[J].World J Hepatol，2017，9(6)：326-332.
, 百拇医药
[2] Xia M F，Lin H D，Yan H M，et al.The association of liver fat content and serum alanine aminotransferase with bone mineral density in middle-aged and elderly Chinese men and postmenopausal women[J].J Transl Med，2016，14：11.
[3] Anstee Q M，Targher G，Day C P.Progression of NAFLD to diabetes mellitus， cardiovascular disease or cirrhosis[J].Nat Rev Gastroenterol Hepatol，2013，10(6)：330-344.
[4] Sharma D L，Lakhani H V，Klug R L，et al.Investigating Molecular Connections of Non-alcoholic Fatty Liver Disease with Associated Pathological Conditions in West Virginia for Biomarker Analysis[J].J Clin Cell Immunol，2017，8(5)：523.
, 百拇医药
[5] Bertot L C，Adams L A.The Natural Course of Non-Alcoholic Fatty Liver Disease[J].Int J Mol Sci，2016，17(5)：774.
[6] Ekstedt M，Hagstr?m H，Nasr P，et al.Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up[J].Hepatology，2015，61(5)：1547-1554.
[7] Angulo P，Kleiner D E，Dam-Larsen S，et al.Liver Fibrosis，but No Other Histologic Features，Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease[J].Gastroenterology，2015，149(2)：389-397.
, http://www.100md.com
[8] Poggiogalle E，Donini L M，Lenzi A，et al.Non-alcoholic fatty liver disease connections with fat-free tissues：A focus on bone and skeletal muscle[J].World J Gastroenterol，2017，23(10)：1747-1757.
[9] Chan H L，Wong G L，Choi P C，et al.Alanine aminotransferase-based algorithms of liver stiffness measurement by transient elastography(Fibroscan) for liver fibrosis in chronic hepatitis B[J].J Viral Hepat，2009，16(1)：36-44.
[10] Castéra L，Vergniol J，Foucher J，et al.Prospective comparison of transient elastography，Fibrotest，APRI，and liver biopsy for the assessment of fibrosis in chronic hepatitis C[J].Gastroenterology，2005，128(2)：343-350.
[11] Arena U，Vizzutti F，Abraldes J G，et al.Reliability of transient elastography for the diagnosis of advanced fibrosis in chronic hepatitis C[J].Gut，2008，57(9)：1288-1293., http://www.100md.com(许雪娟 陈景娴 栾晓军 陈劲松)
综上所述，中老年原发性少肌症与NAFLD具有独立线性负相关。
参考文献
[1] Tovo C V，Fernandes S A，Buss C，et al.Sarcopenia and non-alcoholic fatty liver disease：Is there a relationship？ A systematic review[J].World J Hepatol，2017，9(6)：326-332.
, 百拇医药
[2] Xia M F，Lin H D，Yan H M，et al.The association of liver fat content and serum alanine aminotransferase with bone mineral density in middle-aged and elderly Chinese men and postmenopausal women[J].J Transl Med，2016，14：11.
[3] Anstee Q M，Targher G，Day C P.Progression of NAFLD to diabetes mellitus， cardiovascular disease or cirrhosis[J].Nat Rev Gastroenterol Hepatol，2013，10(6)：330-344.
[4] Sharma D L，Lakhani H V，Klug R L，et al.Investigating Molecular Connections of Non-alcoholic Fatty Liver Disease with Associated Pathological Conditions in West Virginia for Biomarker Analysis[J].J Clin Cell Immunol，2017，8(5)：523.
, 百拇医药
[5] Bertot L C，Adams L A.The Natural Course of Non-Alcoholic Fatty Liver Disease[J].Int J Mol Sci，2016，17(5)：774.
[6] Ekstedt M，Hagstr?m H，Nasr P，et al.Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up[J].Hepatology，2015，61(5)：1547-1554.
[7] Angulo P，Kleiner D E，Dam-Larsen S，et al.Liver Fibrosis，but No Other Histologic Features，Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease[J].Gastroenterology，2015，149(2)：389-397.
, http://www.100md.com
[8] Poggiogalle E，Donini L M，Lenzi A，et al.Non-alcoholic fatty liver disease connections with fat-free tissues：A focus on bone and skeletal muscle[J].World J Gastroenterol，2017，23(10)：1747-1757.
[9] Chan H L，Wong G L，Choi P C，et al.Alanine aminotransferase-based algorithms of liver stiffness measurement by transient elastography(Fibroscan) for liver fibrosis in chronic hepatitis B[J].J Viral Hepat，2009，16(1)：36-44.
[10] Castéra L，Vergniol J，Foucher J，et al.Prospective comparison of transient elastography，Fibrotest，APRI，and liver biopsy for the assessment of fibrosis in chronic hepatitis C[J].Gastroenterology，2005，128(2)：343-350.
[11] Arena U，Vizzutti F，Abraldes J G，et al.Reliability of transient elastography for the diagnosis of advanced fibrosis in chronic hepatitis C[J].Gut，2008，57(9)：1288-1293., http://www.100md.com(许雪娟 陈景娴 栾晓军 陈劲松)
参见：首页 > 保健版 > 家庭健康 > 中年保健 > 中老年健康