儿童OSAHS患者血清IL—17、IL—23的表达及意义(4)
[17] Peppard P E，Young T，Palta M，et al.Prospective study of the association between sleep-disordered breathing and hypertension[J].N Engl J Med，2000，342(19)：1378-1384.
[18] Pai J K，Pischon T，Ma J，et al.Inflammatory markers and the risk of coronary heart disease in men and women[J].N Engl J Med，2004，351(25)：2599-2610.
[19] Kasasbeh E，Chi D S，Krishnaswamy G.Inflammatory aspects of sleep apnea and their cardiovascular consequences[J].South Med J，2006，99(1)：58-67；quiz68-69，81.
, http://www.100md.com
[20]张丽净，宋西成，贾传亮，等.血清中炎症介质和细胞因子与儿童腺样体肥大相关性研究[J].山东大学耳鼻喉眼学报，2014，28(2)：58-61.
[21] Goldbart A D，Tal A.Inflammation and sleep disordered breathing in children：a state-of-the-art review[J].Pediatr Pulmonol，2008，43(12)：1151-1160.
[22] Goldbart A D，Krishna J，Li R C，et al.Inflammatory mediators in exhaled breath condensate of children with obstructive sleep apnea syndrome[J].Chest，2006，130(1)：143-148.
, 百拇医药 [23] Yao Z，Fanslow W C，Seldin M F，et al.Herpesvirus Saimiri encodes a new cytokine，IL-17，which binds to a novel cytokine receptor[J].Immunity，1995，3(6)：811-821.
[24] Yen D，Cheung J，Scheerens H，et al.IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6[J].J Clin Invest，2006，116(5)：1310-1316.
[25] Iwakura Y，Ishigame H.The IL-23/IL-17 axis in inflammation[J].J Clin Invest，2006，116(5)：1218-1222.
, 百拇医药
[26] Zhao J，Lloyd C M，Noble A.Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodeling[J].Mucosal Immunol，2013，6(2)：335-346.
[27] Kawaguchi M，Kokubu F，Fujita J，et al.Role of interleukin-17F in asthma[J].Inflamm Allergy Drug Targets，2009，8(5)：383-389.
[28] Ye J，Liu H，Zhang G，et al.The treg/th17 imbalance in patients with obstructive sleep apnoea syndrome[J].Mediators Inflamm，2012，2012：815308.
, 百拇医药
[29] Anderson M E Jr，Buchwald Z S，Ko J，et al.Patients with pediatric obstructive sleep apnea show altered T-cell populations with a dominant TH17 profile[J].Otolaryngol Head Neck Surg，2014，150(5)：880-886.
[30] Oppmann B，Lesley R，Blom B，et al.Novel p19 protein engages IL-12p40 to form a cytokine，IL-23，with biological activities similar as well as distinct from IL-12[J].Immunity，2000，13(5)：715-725.
[31] Aggarwal S，Ghilardi N，Xie M H，et al.Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17[J].J Biol Chem，2003，278(3)：1910-1914.
, http://www.100md.com
[32] Suzuki E，Mellins E D，Gershwin M E，et al.The IL-23/IL-17 axis in psoriatic arthritis[J].Autoimmun Rev，2014，13(4-5)：496-502.
[33]张婷婷，吉晓菲，李少遊，等.過敏性紫癜患儿Th17、Treg细胞及IL-17、IL-23水平的测定[J].中国免疫学杂志，2016，32(12)：1801-1804.
[34]杨光，郑国玺，张璐瑶，等.IL-17及IL-23在变应性鼻炎及非变应性鼻炎患者血清及鼻腔分泌物中的相关表达及意义[J].临床耳鼻咽喉头颈外科杂志，2015，29(12)：1086-1090.
(收稿日期：2017-01-23) (本文编辑：周亚杰), http://www.100md.com(谢先荣 詹俊杰)
[18] Pai J K，Pischon T，Ma J，et al.Inflammatory markers and the risk of coronary heart disease in men and women[J].N Engl J Med，2004，351(25)：2599-2610.
[19] Kasasbeh E，Chi D S，Krishnaswamy G.Inflammatory aspects of sleep apnea and their cardiovascular consequences[J].South Med J，2006，99(1)：58-67；quiz68-69，81.
, http://www.100md.com
[20]张丽净，宋西成，贾传亮，等.血清中炎症介质和细胞因子与儿童腺样体肥大相关性研究[J].山东大学耳鼻喉眼学报，2014，28(2)：58-61.
[21] Goldbart A D，Tal A.Inflammation and sleep disordered breathing in children：a state-of-the-art review[J].Pediatr Pulmonol，2008，43(12)：1151-1160.
[22] Goldbart A D，Krishna J，Li R C，et al.Inflammatory mediators in exhaled breath condensate of children with obstructive sleep apnea syndrome[J].Chest，2006，130(1)：143-148.
, 百拇医药 [23] Yao Z，Fanslow W C，Seldin M F，et al.Herpesvirus Saimiri encodes a new cytokine，IL-17，which binds to a novel cytokine receptor[J].Immunity，1995，3(6)：811-821.
[24] Yen D，Cheung J，Scheerens H，et al.IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6[J].J Clin Invest，2006，116(5)：1310-1316.
[25] Iwakura Y，Ishigame H.The IL-23/IL-17 axis in inflammation[J].J Clin Invest，2006，116(5)：1218-1222.
, 百拇医药
[26] Zhao J，Lloyd C M，Noble A.Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodeling[J].Mucosal Immunol，2013，6(2)：335-346.
[27] Kawaguchi M，Kokubu F，Fujita J，et al.Role of interleukin-17F in asthma[J].Inflamm Allergy Drug Targets，2009，8(5)：383-389.
[28] Ye J，Liu H，Zhang G，et al.The treg/th17 imbalance in patients with obstructive sleep apnoea syndrome[J].Mediators Inflamm，2012，2012：815308.
, 百拇医药
[29] Anderson M E Jr，Buchwald Z S，Ko J，et al.Patients with pediatric obstructive sleep apnea show altered T-cell populations with a dominant TH17 profile[J].Otolaryngol Head Neck Surg，2014，150(5)：880-886.
[30] Oppmann B，Lesley R，Blom B，et al.Novel p19 protein engages IL-12p40 to form a cytokine，IL-23，with biological activities similar as well as distinct from IL-12[J].Immunity，2000，13(5)：715-725.
[31] Aggarwal S，Ghilardi N，Xie M H，et al.Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17[J].J Biol Chem，2003，278(3)：1910-1914.
, http://www.100md.com
[32] Suzuki E，Mellins E D，Gershwin M E，et al.The IL-23/IL-17 axis in psoriatic arthritis[J].Autoimmun Rev，2014，13(4-5)：496-502.
[33]张婷婷，吉晓菲，李少遊，等.過敏性紫癜患儿Th17、Treg细胞及IL-17、IL-23水平的测定[J].中国免疫学杂志，2016，32(12)：1801-1804.
[34]杨光，郑国玺，张璐瑶，等.IL-17及IL-23在变应性鼻炎及非变应性鼻炎患者血清及鼻腔分泌物中的相关表达及意义[J].临床耳鼻咽喉头颈外科杂志，2015，29(12)：1086-1090.
(收稿日期：2017-01-23) (本文编辑：周亚杰), http://www.100md.com(谢先荣 詹俊杰)