细胞减灭术联合化疗治疗卵巢上皮性癌的效果及对血管内皮生长因子水平的影响(1)
【摘要】 目的：探究细胞减灭术联合化疗治疗卵巢上皮性癌的效果及对血管内皮生长因子(VEGF)水平的影响。方法：选取2013年6月-2017年6月本院收治的卵巢上皮性癌患者40例。按照隨机数字表法将其分为研究组和对照组，各20例。研究组给予细胞减灭术联合化疗治疗，对照组单纯采用细胞减灭术治疗，两组均根据病理结果决定是否需要再次化疗。术后随访5个月，比较两组生存率、病死率、复发率、近期疗效及治疗前后VEGF水平。结果：研究组总有效率、生存率分别为80.0%、65.0%，均高于对照组的45.0%、30.0%，比较差异均有统计学意义(P<0.05)；研究组病死率为5.0%，显著低于对照组30.0%(P<0.05)；治疗后，两组VEGF水平均低于治疗前，且研究组低于对照组，比较差异均有统计学意义(P<0.05)。结论：细胞减灭术联合化疗治疗卵巢上皮性癌能够提高患者生存率，降低病死率，效果显著，值得在临床上推广。
【关键词】 细胞减灭术； 卵巢上皮性癌； 肿瘤； 血管内皮生长因子水平； 化疗
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Effect of Cytoreduction Combined with Chemotherapy in Treatment of Epithelial Ovarian Cancer and the Effect on Level of Vascular Endothelial Growth Factor/KANG Min.//Medical Innovation of China，2018，15(14)：055-058
【Abstract】 Objective：To explore the effect of cytoreduction combined with chemotherapy in treatment of epithelial ovarian cancer and the effect on the level of vascular endothelial growth factor(VEGF).Method：A total of 40 patients with epithelial ovarian cancer admitted in our hospital from June 2013 to June 2017 were selected.According to the random number table method，they were divided into study group and control group，20 cases in each group.The study group was treated with cytoreduction combined with chemotherapy，and control group was treated with cytoreductive surgery alone，they determined whether or not they needed rechemotherapy according to the pathological results.The follow-up was 5 months after operation，the survival rate，mortality，recurrence rate，short-term efficacy and VEGF level before and after treatment between two groups were compared.Result：The total effective rate and survival rate of study group were 80.0% and 65.0% respectively，which were higher than 45.0% and 30.0% of control group，the differences were statistically significant(P<0.05).The mortality of study group was 5.0%，which was lower than 30.0% of control group(P<0.05).After treatment，the VEGF levels of two groups were all lower than those before treatment，and study group was lower than that of control group，the differences were statistically significant(P<0.05).Conclusion：Cytoreduction combined with chemotherapy in treatment of epithelial ovarian cancer can improve the survival rate and reduce the mortality rate，which is worthy of clinical promotion.
【Key words】 Cytoreduction； Epithelial ovarian cancer； Tumor； Vascular endothelial growth factor level； Chemotherapy
First-author’s address：Zhuhai Integrated Chinese and Western Medicine Hospital，Zhuhai 519000，China
doi：10.3969/j.issn.1674-4985.2018.14.013, 百拇医药(康旻)
【关键词】 细胞减灭术； 卵巢上皮性癌； 肿瘤； 血管内皮生长因子水平； 化疗
, http://www.100md.com
Effect of Cytoreduction Combined with Chemotherapy in Treatment of Epithelial Ovarian Cancer and the Effect on Level of Vascular Endothelial Growth Factor/KANG Min.//Medical Innovation of China，2018，15(14)：055-058
【Abstract】 Objective：To explore the effect of cytoreduction combined with chemotherapy in treatment of epithelial ovarian cancer and the effect on the level of vascular endothelial growth factor(VEGF).Method：A total of 40 patients with epithelial ovarian cancer admitted in our hospital from June 2013 to June 2017 were selected.According to the random number table method，they were divided into study group and control group，20 cases in each group.The study group was treated with cytoreduction combined with chemotherapy，and control group was treated with cytoreductive surgery alone，they determined whether or not they needed rechemotherapy according to the pathological results.The follow-up was 5 months after operation，the survival rate，mortality，recurrence rate，short-term efficacy and VEGF level before and after treatment between two groups were compared.Result：The total effective rate and survival rate of study group were 80.0% and 65.0% respectively，which were higher than 45.0% and 30.0% of control group，the differences were statistically significant(P<0.05).The mortality of study group was 5.0%，which was lower than 30.0% of control group(P<0.05).After treatment，the VEGF levels of two groups were all lower than those before treatment，and study group was lower than that of control group，the differences were statistically significant(P<0.05).Conclusion：Cytoreduction combined with chemotherapy in treatment of epithelial ovarian cancer can improve the survival rate and reduce the mortality rate，which is worthy of clinical promotion.
【Key words】 Cytoreduction； Epithelial ovarian cancer； Tumor； Vascular endothelial growth factor level； Chemotherapy
First-author’s address：Zhuhai Integrated Chinese and Western Medicine Hospital，Zhuhai 519000，China
doi：10.3969/j.issn.1674-4985.2018.14.013, 百拇医药(康旻)