孕早期胎儿颈项透明层在产前超声筛查胎儿畸形中的价值(1)
【摘要】 目的：探討孕早期胎儿颈项透明层(NT)在产前超声筛查胎儿畸形(特别是心脏畸形)中的价值。方法：选取2014年1月-2017年6月至本院进行产前筛查且结果为胎儿畸形的孕妇72例为观察组，同期本院产检胎儿正常孕妇100例为对照组。所有孕妇均给予常规超声检查，并进行NT测量。比较两组孕妇孕11、12、13周NT值，追踪两组孕妇的生产结局，记录观察组胎儿畸形情况。结果：孕11～13周时，观察组NT值均高于对照组，比较差异均有统计学意义(P<0.05)。观察组72例胎儿中均为胎儿畸形，其中42例在孕11～13周发现，30例在孕13周后发现；畸形胎儿中染色体异常45例；67例孕妇采用人工流产终止妊娠，5例胎儿畸形轻微，父母决定保留胎儿，正常生产。对照组100例胎儿均为健康胎儿，正常生产，母婴平安，无胎儿畸形。观察组72例胎儿畸形中先天性心脏病所占比例最高，共计21例，占29.17%；其次为唇腭裂19例(26.39%)；食管闭锁与食管瘘胎儿最少，各1例，共计2例，占2.78%。结论：孕早期NT检查在产前超声筛查胎儿畸形中有重要的应用价值，能够为胎儿发育的健康程度以及染色体异常情况的预测提供重要依据。
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【关键词】 孕早期； 胎儿； 颈项透明层； 产前筛查； 畸形
【Abstract】 Objective：To investigate the value of early pregnancy nuchal translucency in prenatal ultrasound screening for fetal malformations(especially cardiac malformations).Method：A total of 72 pregnant women who had prenatal screening and the results were fetal malformations from January 2014 to June 2017 were selected as observation group，and in the same period，100 normal fetuses were selected as control group.All pregnant women were given routine ultrasound examination and NT measurement. NT values of pregnant women at 11，12 and 13 weeks in two groups were compared，the outcome of two groups were tracked，and fetal malformations in observation group were recorded.Result：At 11-13 weeks of pregnancy，NT value of observation group were higher than those of control group，the differences were statistically significant(P<0.05).In the observation group，72 fetuses were fetal malformation，of which 42 cases were found at 11-13 weeks of pregnancy，30 cases were found after 13 weeks of pregnancy，45 cases were chromosomal abnormalities，67 cases were aborted by abortion，5 cases of fetal malformation were mild，and the parents decided to keep the fetus and normal production.In control group，100 fetuses were healthy fetus，normal production，maternal and child safety，no fetal malformation.72 cases of fetal malformation in the observation group，the proportion of congenital heart disease was the highest，a total of 21 cases，accounting for 29.17%.The second was cleft lip and palate in 19 cases(26.39%).The esophagus atresia and the esophagus fistula were the least in the fetus，1 case each，a total of 2 cases，accounting for 2.78%.Conclusion：NT examination in the early pregnancy is of great value in prenatal ultrasound screening for fetal malformation，and it can provide important basis for the health of fetal development and the prediction of abnormal chromosomes.
【Key words】 Early pregnancy； Fetus； Nuchal translucency； Prenatal screening； Malformation, 百拇医药(张微)
, http://www.100md.com
【关键词】 孕早期； 胎儿； 颈项透明层； 产前筛查； 畸形
【Abstract】 Objective：To investigate the value of early pregnancy nuchal translucency in prenatal ultrasound screening for fetal malformations(especially cardiac malformations).Method：A total of 72 pregnant women who had prenatal screening and the results were fetal malformations from January 2014 to June 2017 were selected as observation group，and in the same period，100 normal fetuses were selected as control group.All pregnant women were given routine ultrasound examination and NT measurement. NT values of pregnant women at 11，12 and 13 weeks in two groups were compared，the outcome of two groups were tracked，and fetal malformations in observation group were recorded.Result：At 11-13 weeks of pregnancy，NT value of observation group were higher than those of control group，the differences were statistically significant(P<0.05).In the observation group，72 fetuses were fetal malformation，of which 42 cases were found at 11-13 weeks of pregnancy，30 cases were found after 13 weeks of pregnancy，45 cases were chromosomal abnormalities，67 cases were aborted by abortion，5 cases of fetal malformation were mild，and the parents decided to keep the fetus and normal production.In control group，100 fetuses were healthy fetus，normal production，maternal and child safety，no fetal malformation.72 cases of fetal malformation in the observation group，the proportion of congenital heart disease was the highest，a total of 21 cases，accounting for 29.17%.The second was cleft lip and palate in 19 cases(26.39%).The esophagus atresia and the esophagus fistula were the least in the fetus，1 case each，a total of 2 cases，accounting for 2.78%.Conclusion：NT examination in the early pregnancy is of great value in prenatal ultrasound screening for fetal malformation，and it can provide important basis for the health of fetal development and the prediction of abnormal chromosomes.
【Key words】 Early pregnancy； Fetus； Nuchal translucency； Prenatal screening； Malformation, 百拇医药(张微)
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