瘦素受体基因rs1137101位点多态性与2型糖尿病的Meta分析(1)
【摘要】 目的：采用Meta分析的方法綜合系统地评价瘦素受体基因rs1137101位点多态性与2型糖尿病的相关关系。方法：通过检索CNKI、CBM、PubMed、万方等数据库收集相关文献，采用Stata 11.0软件进行Meta分析。结果：最终纳入10篇病例对照文献，6 324例研究对象，其中2型糖尿病患者3 633例(病例组)，对照组2 691例。Meta分析结果显示，病例组和对照组基因频率分布比较差异有统计学意义(P<0.05)，携带A等位基因者可能增加T2DM的患病风险[A vs G：OR值(95%CI)=1.599(1.337，1.913)]，病例组和对照组基因型分布比较差异无统计学意义[AA vs GG：OR值(95%CI)=1.069(0.787，1.453)：(AA+AG) vs GG：OR值(95%CI)=1.040(0.905，1.194)：AA vs (GG+AG)：OR值(95%CI)=0.995(0.798，1.239)]。按种族进行亚组分析，在等位基因模式下，黄种人群携带A等位基因者是携带G等位基因者的1.808倍[OR值(95%CI)=1.808(1.571，2.081)]，白种人群携带A等位基因者是携带G等位基因者的1.261倍[OR值(95%CI)=1.261(1.052，1.511)]，病例组和对照组基因型分布差异均无统计学意义[黄种人AA vs GG：OR值(95%CI)=1.020(0.620，1.679)：AA vs (AG+GG)：OR值(95%CI)=1.032(0.892，1.194)；(AA+AG) vs GG：OR值(95%CI)=1.019(0.875，1.187)；白种人：AA vs GG：OR值(95%CI)=1.101(0.746，1.623)：AA vs (AG+GG)：OR值(95%CI)=0.990(0.775，1.265)；(AA+AG) vs GG：OR值(95%CI)=1.144(0.818，1.600)]。结论：LEPRrs1137101位点多态性与2型糖尿病存在关联，等位基因A可能会增加2型糖尿病的患病风险。
, 百拇医药
【关键词】 瘦素受体基因； 2型糖尿病； 基因多态性； Meta分析
【Abstract】 Objective：To evaluate whether LEPR gene rs1137101 polymorphism was correlated with T2DM.Method：Literatures were retrieved from CNKI，CBM，PubMed and WanFang databases，etc.Meta-analysis was performed using Stata 11.0 software.Results A total of 6 324 subjects from 10 literatures were identified，including 3 633 cases of T2DM and 2 691 cases as control.Meta-analysis showed that there was a significant correlation between LEPRrs1137101and T2DM for allele contrast genetic model[A vs G：OR(95%CI)=1.599(1.337，1.913)]，there was no significant correlation between rs1137101and T2DM under recessive genetic model，dominant genetic model as well as additive genetic model[AA vs GG：OR(95%CI)=1.069(0.787，1.453)：(AA+AG) vs GG：OR(95%CI)=1.040(0.905，1.194)：AA vs (GG+AG)：OR(95%CI)=0.995(0.798，1.239)]。Subgroup analysis by race showed that LEPRrs1137101 and T2DM for allele contrast genetic model[Asians：OR(95%CI)=1.808(1.571，2.081)，Caucasians：OR(95%CI)=1.261(1.052，1.511)]and there was no significant correlation between rs1137101 and T2DM under recessive genetic model， dominant genetic model as well as additive genetic model[Asians：AA vs GG：OR(95%CI)=1.020(0.620，1.679)：AA vs (AG+GG)：OR(95%CI)=1.032(0.892，1.194)；(AA+AG) vs GG：OR(95%CI)=1.019(0.875，1.187)；Caucasians：AA vs GG：OR(95%CI)=1.101(0.746，1.623)：AA vs (AG+GG)：OR(95%CI)=0.990(0.775，1.265)；(AA+AG) vs GG：OR(95%CI)=1.144(0.818，1.600)].Conclusion：LEPR gene rs1137101 is correlated significantly with T2DM，the allele A carriers are at a high risk of T2DM.
【Key words】 LEPR Gene； T2DM； Polymorphism； Meta-analysis, 百拇医药(周婧婧)
, 百拇医药
【关键词】 瘦素受体基因； 2型糖尿病； 基因多态性； Meta分析
【Abstract】 Objective：To evaluate whether LEPR gene rs1137101 polymorphism was correlated with T2DM.Method：Literatures were retrieved from CNKI，CBM，PubMed and WanFang databases，etc.Meta-analysis was performed using Stata 11.0 software.Results A total of 6 324 subjects from 10 literatures were identified，including 3 633 cases of T2DM and 2 691 cases as control.Meta-analysis showed that there was a significant correlation between LEPRrs1137101and T2DM for allele contrast genetic model[A vs G：OR(95%CI)=1.599(1.337，1.913)]，there was no significant correlation between rs1137101and T2DM under recessive genetic model，dominant genetic model as well as additive genetic model[AA vs GG：OR(95%CI)=1.069(0.787，1.453)：(AA+AG) vs GG：OR(95%CI)=1.040(0.905，1.194)：AA vs (GG+AG)：OR(95%CI)=0.995(0.798，1.239)]。Subgroup analysis by race showed that LEPRrs1137101 and T2DM for allele contrast genetic model[Asians：OR(95%CI)=1.808(1.571，2.081)，Caucasians：OR(95%CI)=1.261(1.052，1.511)]and there was no significant correlation between rs1137101 and T2DM under recessive genetic model， dominant genetic model as well as additive genetic model[Asians：AA vs GG：OR(95%CI)=1.020(0.620，1.679)：AA vs (AG+GG)：OR(95%CI)=1.032(0.892，1.194)；(AA+AG) vs GG：OR(95%CI)=1.019(0.875，1.187)；Caucasians：AA vs GG：OR(95%CI)=1.101(0.746，1.623)：AA vs (AG+GG)：OR(95%CI)=0.990(0.775，1.265)；(AA+AG) vs GG：OR(95%CI)=1.144(0.818，1.600)].Conclusion：LEPR gene rs1137101 is correlated significantly with T2DM，the allele A carriers are at a high risk of T2DM.
【Key words】 LEPR Gene； T2DM； Polymorphism； Meta-analysis, 百拇医药(周婧婧)
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