经尿道钬激光膀胱肿瘤剜除术与电切术治疗浅表性肿瘤的疗效比较(1)
【摘要】 目的：探討经尿道钬激光膀胱肿瘤剜除术与电切术治疗浅表性肿瘤的效果。方法：选取2016年5月-2017年5月本院收治的浅表性膀胱肿瘤患者58例。按照随机数字表法将其分为研究组和对照组，各29例。对照组应用经尿道电切术治疗，研究组应用经尿道钬激光剜除术治疗。比较两组术中出血量、膀胱冲洗时间、尿管置留时间、住院时长、术后1年肿瘤预后标志物情况(P53蛋白和KI-67蛋白)、相关并发症发生情况。结果：研究组术中出血量、膀胱冲洗时间、尿管留置时间、住院总时长均少于对照组，比较差异均有统计学意义(P<0.05);研究组P53、KI-67蛋白阴性率分别为82.76%、89.66%，均高于对照组的48.28%、37.93%，比较差异均有统计学意义(P<0.05);研究组并发症发生率为0，低于对照组的17.24%(P<0.05)。结论：经尿道钬激光膀胱肿瘤剜除术治疗浅表性膀胱肿瘤操作简单，疗效显著，与电切术比较，更具有优越性，可作为治疗该肿瘤的可行性途径之一，对患者而言提高治疗效果和术后满意度具有重要意义，因此建议在临床上进一步推广应用。
【关键词】 经尿道钬激光膀胱肿瘤剜除术; 经尿道电切术; 浅表性肿瘤
【Abstract】 Objective：To investigate the curative effect of transurethral holmium laser enucleation of bladder tumors and electrocision in treatment of superficial tumors.Method：A total of 58 patients with superficial bladder tumors admitted to our hospital from May 2016 to May 2017 were selected.According to the random number table method，they were divided into study group and control group，29 cases in each group.The control group was treated with transurethral electrotomy，and study group was treated with transurethral holmium laser enucleation.The intraoperative bleeding volume，bladder irrigation time，indwelling time of urinary catheter，length of hospitalization，prognostic markers(P53 protein and KI-67 protein)of 1 year after operation and related complications between two groups were compared.Result：The intraoperative bleeding volume，bladder irrigation time，indwelling time of urinary catheter，length of hospitalization in study group were less than those of control group，the differences were statistically significant(P<0.05).The negative rates of P53 and KI-67 protein in study group were 82.76% and 89.66% respectively，which were higher than 48.28% and 37.93% in control group，the differences were statistically significant(P<0.05).The incidence of complications in study group was 0，which was lower than 17.24% in control group(P<0.05).Conclusion：Transurethral holmium laser enucleation of bladder tumors for superficial bladder tumors is simple and effective.Compared with electrotomy，it has more advantages and can be used as one of the feasible ways to treat this tumor.It is important for patients to improve the curative effect and satisfaction after operation.Therefore，it is suggested to further promote the clinical application.
【Key words】 Transurethral holmium laser enucleation of bladder tumor; Transurethral electrotomy; Superficial bladder tumors
First-author’s address：Qianjiang Central Hospital of Hubei，Qianjiang 433100，China, http://www.100md.com(王新)
【关键词】 经尿道钬激光膀胱肿瘤剜除术; 经尿道电切术; 浅表性肿瘤
【Abstract】 Objective：To investigate the curative effect of transurethral holmium laser enucleation of bladder tumors and electrocision in treatment of superficial tumors.Method：A total of 58 patients with superficial bladder tumors admitted to our hospital from May 2016 to May 2017 were selected.According to the random number table method，they were divided into study group and control group，29 cases in each group.The control group was treated with transurethral electrotomy，and study group was treated with transurethral holmium laser enucleation.The intraoperative bleeding volume，bladder irrigation time，indwelling time of urinary catheter，length of hospitalization，prognostic markers(P53 protein and KI-67 protein)of 1 year after operation and related complications between two groups were compared.Result：The intraoperative bleeding volume，bladder irrigation time，indwelling time of urinary catheter，length of hospitalization in study group were less than those of control group，the differences were statistically significant(P<0.05).The negative rates of P53 and KI-67 protein in study group were 82.76% and 89.66% respectively，which were higher than 48.28% and 37.93% in control group，the differences were statistically significant(P<0.05).The incidence of complications in study group was 0，which was lower than 17.24% in control group(P<0.05).Conclusion：Transurethral holmium laser enucleation of bladder tumors for superficial bladder tumors is simple and effective.Compared with electrotomy，it has more advantages and can be used as one of the feasible ways to treat this tumor.It is important for patients to improve the curative effect and satisfaction after operation.Therefore，it is suggested to further promote the clinical application.
【Key words】 Transurethral holmium laser enucleation of bladder tumor; Transurethral electrotomy; Superficial bladder tumors
First-author’s address：Qianjiang Central Hospital of Hubei，Qianjiang 433100，China, http://www.100md.com(王新)