医用生物胶体分散剂对改善压疮患者TNF-α和VEGF水平的效果分析(1)
【摘要】 目的：探讨医用生物胶体分散剂对改善压疮患者TNF-α和血管内皮生长因子(VEGF)水平的效果。方法：选取赣南医学院第二附属医院2017年5月-2018年5月收治的压疮患者80例，采用随机数字表法将患者分为观察组和对照组，各40例。对照组给予传统碘伏消毒以及湿-干法换药，观察组在此基础上给予医用生物胶体分散剂治疗。观察两组患者治疗前后TNF-α、VEGF水平，以及临床效果。结果：治疗后，观察组TNF-α和VEGF水平均明显下降(P<0.01)，且观察组TNF-α和VEGF水平均低于对照组，差异均有统计学意义(P<0.01);观察组治疗总有效率(95.00%)明显高于对照组(72.50%)，差异有统计学意义(P<0.01)。结论：医用生物胶体分散剂可明显改善压疮患者的TNF-α、VEGF水平，促进创面愈合。
【关键词】 医用生物胶体分散剂; 压疮; TNF-α; VEGF
【Abstract】 Objective：To investigate the effects of medical biological gel dispersant on amelioration of TNF-α and vascular endothelial growth factor(VEGF)levels in patients with pressure ulcer.Method：80 patients with pressure ulcer were selected in the second affiliated hospital of Gannan medical college from May 2017 to May 2018，and divided into observation group and control group according to the random number table method，40 cases in each group.The control group was given traditional iodophor disinfection and wet-dry method，on this basis，the observation group was given medical biological gel dispersant treatment.The levels of TNF-α and VEGF before and after treatment and clinical effect were observed in the two groups.Result：After treatment，the levels of TNF-α and VEGF in the observation group were significantly decreased and lower than those of the control group，the differences were statistically significant(P<0.01).The total effective rate of treatment in the observation group(95.00%)was higher than that in the control group(72.50%)，the difference was statistically significant(P<0.01).Conclusion：Medical biological gel dispersant can significantly ameliorate the levels of TNF-α and VEGF in patients with pressure ulcers and promote wound healing.
【Key words】 Medical biological gel dispersant; Pressure ulcer; TNF-α; VEGF
First-author’s address：The Second Affiliated Hospital of Gannan Medical College，Ganzhou 341600，China
doi：10.3969/j.issn.1674-4985.2019.14.036
壓疮又称压力性溃疡、褥疮，主要是由于局部组织长期受压，发生持续性缺血、缺氧及营养不良而导致的组织溃烂坏死，多发于长期卧床患者，其中下肢活动障碍患者及老年人为高危人群[1]。有研究提示在所有护理风险中压疮占据了近10%的比例。据文献[2]统计分析对综合性医院调查压疮现患率为1.67%，医院获得性压疮发生率为0.68%。而国内个别三甲医院统计发现发生压疮最多的年龄段是70～89岁(占64.5%)[3]。其他医院数据也都大致相当，压疮具有病程长、反复发作、预后差等特点，严重影响患者疾病康复以及生活质量，甚至造成患者死亡，也是长期困扰医务人员的技术难题。及时清创以及促进肉芽生长是治疗压疮的关键。本研究将医用生物胶体分散剂应用于压疮的治疗中，通过观察患者炎性因子水平的改善情况探讨其临床疗效。现报道如下。
1 资料与方法
1.1 一般资料 选取赣南医学院第二附属医院2017年5月-2018年5月收治的压疮住院患者80例。纳入标准：年龄≥18岁;符合压疮诊断标准;Ⅱ～Ⅳ期;病程≥3 d。排除标准：近3个月内接受过抗凝治疗者;存在出血倾向者;合并糖尿病等代谢性疾病患者;认知功能障碍者。按照随机数字表法将患者分为观察组和对照组，各40例。所有患者均知情同意，本研究经医院伦理委员会批准。, 百拇医药(邹文妹 黄俊喜 毛君晓 熊云珑 张雨云)
【关键词】 医用生物胶体分散剂; 压疮; TNF-α; VEGF
【Abstract】 Objective：To investigate the effects of medical biological gel dispersant on amelioration of TNF-α and vascular endothelial growth factor(VEGF)levels in patients with pressure ulcer.Method：80 patients with pressure ulcer were selected in the second affiliated hospital of Gannan medical college from May 2017 to May 2018，and divided into observation group and control group according to the random number table method，40 cases in each group.The control group was given traditional iodophor disinfection and wet-dry method，on this basis，the observation group was given medical biological gel dispersant treatment.The levels of TNF-α and VEGF before and after treatment and clinical effect were observed in the two groups.Result：After treatment，the levels of TNF-α and VEGF in the observation group were significantly decreased and lower than those of the control group，the differences were statistically significant(P<0.01).The total effective rate of treatment in the observation group(95.00%)was higher than that in the control group(72.50%)，the difference was statistically significant(P<0.01).Conclusion：Medical biological gel dispersant can significantly ameliorate the levels of TNF-α and VEGF in patients with pressure ulcers and promote wound healing.
【Key words】 Medical biological gel dispersant; Pressure ulcer; TNF-α; VEGF
First-author’s address：The Second Affiliated Hospital of Gannan Medical College，Ganzhou 341600，China
doi：10.3969/j.issn.1674-4985.2019.14.036
壓疮又称压力性溃疡、褥疮，主要是由于局部组织长期受压，发生持续性缺血、缺氧及营养不良而导致的组织溃烂坏死，多发于长期卧床患者，其中下肢活动障碍患者及老年人为高危人群[1]。有研究提示在所有护理风险中压疮占据了近10%的比例。据文献[2]统计分析对综合性医院调查压疮现患率为1.67%，医院获得性压疮发生率为0.68%。而国内个别三甲医院统计发现发生压疮最多的年龄段是70～89岁(占64.5%)[3]。其他医院数据也都大致相当，压疮具有病程长、反复发作、预后差等特点，严重影响患者疾病康复以及生活质量，甚至造成患者死亡，也是长期困扰医务人员的技术难题。及时清创以及促进肉芽生长是治疗压疮的关键。本研究将医用生物胶体分散剂应用于压疮的治疗中，通过观察患者炎性因子水平的改善情况探讨其临床疗效。现报道如下。
1 资料与方法
1.1 一般资料 选取赣南医学院第二附属医院2017年5月-2018年5月收治的压疮住院患者80例。纳入标准：年龄≥18岁;符合压疮诊断标准;Ⅱ～Ⅳ期;病程≥3 d。排除标准：近3个月内接受过抗凝治疗者;存在出血倾向者;合并糖尿病等代谢性疾病患者;认知功能障碍者。按照随机数字表法将患者分为观察组和对照组，各40例。所有患者均知情同意，本研究经医院伦理委员会批准。, 百拇医药(邹文妹 黄俊喜 毛君晓 熊云珑 张雨云)