依达拉奉联合溶栓治疗对急性脑梗死患者抗氧化能力及脑血流的影响研究(1)
【摘要】 目的：观察与研究依达拉奉联合溶栓治疗对急性脑梗死患者抗氧化能力及脑血流的影响。方法：选取2017年1月-2018年12月本院收治的86例急性脑梗死患者为研究对象，根据治疗方式的不同分为对照组(溶栓治疗组)43例和观察组(依达拉奉联合溶栓治疗组)43例。比较两组患者的临床疗效、治疗前后的抗氧化能力及脑血流指标。结果：观察组的临床疗效显著优于对照组，差异有统计学意义(P<0.05)。治疗前两组的抗氧化能力及脑血流指标比较，差异无均统计学意义(P>0.05);治療后观察组的抗氧化能力及脑血流指标均优于对照组，差异均有统计学意义(P<0.05)。结论：依达拉奉联合溶栓治疗在急性脑梗死患者中的应用效果较好，且对抗氧化能力及脑血流均有积极的改善作用。
【关键词】 依达拉奉; 溶栓治疗; 急性脑梗死; 抗氧化能力; 脑血流
Study on the Influence of Edaravone Combined with Thrombolytic Therapy for the Antioxidant Capacity and Cerebral Blood Flow of Patients with Acute Cerebral Infarction/LIANG Guocong，CHEN Weichan，LIN Lifeng，et al.//Medical Innovation of China，2019，16(19)：0-029
【Abstract】 Objective：To observe and study the influence of Edaravone combined with thrombolytic therapy for the antioxidant capacity and cerebral blood flow of patients with acute cerebral infarction.Method：86 patients with acute cerebral infarction from January 2017 to December 2018 were chosen as the study objects，they were divided into control group(thrombolytic therapy group)of 43 cases and observation group(Edaravone combined with thrombolytic therapy group)of 43 cases according to the differences of treatment method.The clinical effect，antioxidant capacity and cerebral blood flow indexes before and after the treatment of two groups were compared.Result：The clinical effect of observation group was significantly better than that of control group，there was statistically significant difference(P<0.05).The antioxidant capacity and cerebral blood flow indexes of two groups before the treatment were compared，there were no statistically significant differences(P>0.05);the antioxidant capacity and cerebral blood flow indexes of observation group after the treatment were significantly better than those of control group，there were statistically significant differences(P<0.05).Conclusion：The application effect of Edaravone combined with thrombolytic therapy in the patients with acute cerebral infarction is better，it has active improvement role for antioxidant capacity and cerebral blood flow of patients.
【Key words】 Edaravone; Thrombolytic therapy; Acute cerebral infarction; Antioxidant capacity; Cerebral blood flow
First-author’s address：Affiliated Hospital of Guangdong Medical University，Zhanjiang 524001，China
doi：10.3969/j.issn.1674-4985.2019.19.007
急性脑梗死的预后差，具有较高的致残率及致死率，而早期的血供改善与神经功能损伤控制是疾病治疗的重点。临床中对于急性脑梗死的治疗中，溶栓治疗具有极为重要的作用，其可通过有效的溶栓作用对患者的血供恢复起到积极的作用[1-2]，但对患者疗效的进一步提升空间仍较大。依达拉奉作为在脑梗死患者中应用率不断提升的一类药物，其具有较好的脑保护作用[3]。本研究就依达拉奉联合溶栓治疗对急性脑梗死患者抗氧化能力及脑血流的影响进行探究，现将结果总结如下。, http://www.100md.com(梁国聪 陈伟婵 林力峰 揭碗辛 麦晖)
【关键词】 依达拉奉; 溶栓治疗; 急性脑梗死; 抗氧化能力; 脑血流
Study on the Influence of Edaravone Combined with Thrombolytic Therapy for the Antioxidant Capacity and Cerebral Blood Flow of Patients with Acute Cerebral Infarction/LIANG Guocong，CHEN Weichan，LIN Lifeng，et al.//Medical Innovation of China，2019，16(19)：0-029
【Abstract】 Objective：To observe and study the influence of Edaravone combined with thrombolytic therapy for the antioxidant capacity and cerebral blood flow of patients with acute cerebral infarction.Method：86 patients with acute cerebral infarction from January 2017 to December 2018 were chosen as the study objects，they were divided into control group(thrombolytic therapy group)of 43 cases and observation group(Edaravone combined with thrombolytic therapy group)of 43 cases according to the differences of treatment method.The clinical effect，antioxidant capacity and cerebral blood flow indexes before and after the treatment of two groups were compared.Result：The clinical effect of observation group was significantly better than that of control group，there was statistically significant difference(P<0.05).The antioxidant capacity and cerebral blood flow indexes of two groups before the treatment were compared，there were no statistically significant differences(P>0.05);the antioxidant capacity and cerebral blood flow indexes of observation group after the treatment were significantly better than those of control group，there were statistically significant differences(P<0.05).Conclusion：The application effect of Edaravone combined with thrombolytic therapy in the patients with acute cerebral infarction is better，it has active improvement role for antioxidant capacity and cerebral blood flow of patients.
【Key words】 Edaravone; Thrombolytic therapy; Acute cerebral infarction; Antioxidant capacity; Cerebral blood flow
First-author’s address：Affiliated Hospital of Guangdong Medical University，Zhanjiang 524001，China
doi：10.3969/j.issn.1674-4985.2019.19.007
急性脑梗死的预后差，具有较高的致残率及致死率，而早期的血供改善与神经功能损伤控制是疾病治疗的重点。临床中对于急性脑梗死的治疗中，溶栓治疗具有极为重要的作用，其可通过有效的溶栓作用对患者的血供恢复起到积极的作用[1-2]，但对患者疗效的进一步提升空间仍较大。依达拉奉作为在脑梗死患者中应用率不断提升的一类药物，其具有较好的脑保护作用[3]。本研究就依达拉奉联合溶栓治疗对急性脑梗死患者抗氧化能力及脑血流的影响进行探究，现将结果总结如下。, http://www.100md.com(梁国聪 陈伟婵 林力峰 揭碗辛 麦晖)