莫西沙星与左氧氟沙星治疗耐多药肺结核患者的疗效比较(1)
【摘要】 目的：比較莫西沙星与左氧氟沙星治疗耐多药肺结核(MDR-PTB)患者的临床疗效。
方法：84例MDR-PTB患者根据随机数字表法分为对照组与研究组，每组42例。两组均予以常规抗结核化疗方案治疗，对照组在此基础上加用左氧氟沙星片口服治疗，观察组则加用莫西沙星片口服治疗，两组治疗时间均为12个月。比较两组治疗效果及病灶吸收、空洞闭合、痰菌转阴情况，同时记录两组治疗期间药物不良反应发生情况。结果：观察组治疗总有效率(92.86%)明显高于对照组(71.43%)，差异有统计学意义(P<0.05);观察组治疗第6、9、12个月时痰菌转阴率均明显高于对照组(P<0.05);观察组病灶吸收及空洞改善情况均明显优于对照组(P<0.05);观察组药物不良反应发生率(9.52%)明显低于对照组(26.19%)，差异有统计学意义(P<0.05)。结论：莫西沙星治疗MDR-PTB患者的临床疗效优于左氧氟沙星，可促进病灶吸收、空洞闭合及痰菌转阴，明显减少不良反应发生率。
【关键词】 莫西沙星; 左氧氟沙星; 耐多药肺结核
Comparison Efficacy of Moxifloxacin and Levofloxacin in the Treatment of Patients with Multidrug-Resistant Pulmonary Tuberculosis/HAO Wei，SHANG Xiaosan，LIU Chungang.//Medical Innovation of China，2019，16(21)：0-065
【Abstract】 Objective：To compare the clinical efficacy of Moxifloxacin and Levofloxacin in the treatment of patients with multidrug-resistant pulmonary tuberculosis(MDR-PTB).Method：84 cases of MDR-PTB patients were divided into control group and observation group according to the random number table method，42 cases in each group.Both groups were treated with conventional anti-tuberculosis chemo therapy.The control group was treated with Levofloxacin Tablets orally，while the observation group was treated with Moxifloxacin Tablets orally.Both groups were treated for 12 months.The treatment effect，focus absorption，cavity closure and sputum turning negative of the two groups were compared，and the occurrence of adverse drug reactions during the treatment of the two groups were recorded in detail.Result：The total effective rate of the observation group(92.86%)was significantly higher than that of the control group(71.43%)，the difference was statistically significant(P<0.05).The turning negative rate of sputum bacteria at the 6th，9th and 12th month of treatment in the observation group were significantly higher than those in the control group(P<0.05).The focus absorption and cavity improvement in the observation group were significantly better than those in the control group(P<0.05).The incidence of adverse drug reactions in the observation group(9.52%)was significantly lower than that in the control group(26.19%)，the difference was statistically significant(P<0.05).Conclusion：The clinical efficacy of Moxifloxacin in the treatment of MDR-PTB patients is better than Levofloxacin.It can promote focus absorption，cavity closure and sputum turning negative，and significantly reduce the incidence of adverse reactions.
【Key words】 Moxifloxacin; Levofloxacin; Multidrug-resistant pulmonary tuberculosis, 百拇医药(郝伟 尚小三 刘纯钢)
方法：84例MDR-PTB患者根据随机数字表法分为对照组与研究组，每组42例。两组均予以常规抗结核化疗方案治疗，对照组在此基础上加用左氧氟沙星片口服治疗，观察组则加用莫西沙星片口服治疗，两组治疗时间均为12个月。比较两组治疗效果及病灶吸收、空洞闭合、痰菌转阴情况，同时记录两组治疗期间药物不良反应发生情况。结果：观察组治疗总有效率(92.86%)明显高于对照组(71.43%)，差异有统计学意义(P<0.05);观察组治疗第6、9、12个月时痰菌转阴率均明显高于对照组(P<0.05);观察组病灶吸收及空洞改善情况均明显优于对照组(P<0.05);观察组药物不良反应发生率(9.52%)明显低于对照组(26.19%)，差异有统计学意义(P<0.05)。结论：莫西沙星治疗MDR-PTB患者的临床疗效优于左氧氟沙星，可促进病灶吸收、空洞闭合及痰菌转阴，明显减少不良反应发生率。
【关键词】 莫西沙星; 左氧氟沙星; 耐多药肺结核
Comparison Efficacy of Moxifloxacin and Levofloxacin in the Treatment of Patients with Multidrug-Resistant Pulmonary Tuberculosis/HAO Wei，SHANG Xiaosan，LIU Chungang.//Medical Innovation of China，2019，16(21)：0-065
【Abstract】 Objective：To compare the clinical efficacy of Moxifloxacin and Levofloxacin in the treatment of patients with multidrug-resistant pulmonary tuberculosis(MDR-PTB).Method：84 cases of MDR-PTB patients were divided into control group and observation group according to the random number table method，42 cases in each group.Both groups were treated with conventional anti-tuberculosis chemo therapy.The control group was treated with Levofloxacin Tablets orally，while the observation group was treated with Moxifloxacin Tablets orally.Both groups were treated for 12 months.The treatment effect，focus absorption，cavity closure and sputum turning negative of the two groups were compared，and the occurrence of adverse drug reactions during the treatment of the two groups were recorded in detail.Result：The total effective rate of the observation group(92.86%)was significantly higher than that of the control group(71.43%)，the difference was statistically significant(P<0.05).The turning negative rate of sputum bacteria at the 6th，9th and 12th month of treatment in the observation group were significantly higher than those in the control group(P<0.05).The focus absorption and cavity improvement in the observation group were significantly better than those in the control group(P<0.05).The incidence of adverse drug reactions in the observation group(9.52%)was significantly lower than that in the control group(26.19%)，the difference was statistically significant(P<0.05).Conclusion：The clinical efficacy of Moxifloxacin in the treatment of MDR-PTB patients is better than Levofloxacin.It can promote focus absorption，cavity closure and sputum turning negative，and significantly reduce the incidence of adverse reactions.
【Key words】 Moxifloxacin; Levofloxacin; Multidrug-resistant pulmonary tuberculosis, 百拇医药(郝伟 尚小三 刘纯钢)