健脾和胃行气法治疗晚期消化道恶性肿瘤(脾虚气滞型)化疗引起的消化道不良反应的临床观察(1)
【摘要】 目的：探討健脾和胃行气法对晚期消化道恶性肿瘤化疗引起的消化道不良反应的临床疗效。方法：将2014年12月-2017年10月因晚期消化道恶性肿瘤(脾虚气滞型)于本院行化疗干预的84例患者纳入研究，按照随机数字表法将患者分为对照组和观察组，各42例。对照组患者采用顺铂联合卡培他滨化疗，观察组患者在对照组基础上行健脾和胃行气法治疗。比较两组患者治疗前后脘腹不适、口淡无味和食欲下降各项症状积分，血红蛋白(Hb)、白蛋白(ALB)和血清总蛋白(TP)水平改善情况以及临床效果。结果：治疗前，两组患者脘腹不适、口淡无味和食欲下降各项症状积分比较，差异均无统计学意义(P>0.05);治疗后，两组患者脘腹不适、口淡无味、食欲下降各项症状积分均较治疗前升高，差异均有统计学意义(P<0.05);且治疗后观察组各项症状积分升高幅度均小于对照组，差异均有统计学意义(P<0.05)。治疗前，两组患者Hb、ALB和TP水平比较，差异均无统计学意义(P>0.05);治疗后，两组患者Hb、ALB和TP水平较化疗前均降低，差异均有统计学意义(P<0.05);且治疗后观察组患者Hb、ALB和TP水平均显著高于对照组，差异均有统计学意义(P<0.05)。观察组患者的总有效率为76.19%，明显高于对照组的54.76%，差异有统计学意义(P<0.05)。结论：健脾和胃行气法对晚期消化道恶性肿瘤化疗引起的消化道不良反应效果显著，且可提高化疗效果，值得推广。
【关键词】 健脾和胃行气法 消化道恶性肿瘤 化疗 消化道不良反应
Clinical Observation of Invigorating Spleen and Stomach for the Treatment of Adverse Reactions of Digestive Tract Caused by Chemotherapy for Advanced Malignant Tumor of Digestive Tract (Pixu Qizhi Type) /XIE Mingjun， JIANG Jielin， GE Lai’an. //Medical Innovation of China， 2019， 16(29)： 00-013
[Abstract] Objective： To explore the clinical efficacy of invigorating spleen and stomach for adverse reactions of digestive tract caused by chemotherapy for advanced malignant tumor of digestive tract. Method： From December 2014 to October 2017， 84 patients receiving chemotherapy intervention in our hospital due to advanced digestive tract malignant tumor (Pixu Qizhi Type) were included in the study. According to the random number table method， the patients were divided into the control group and the observation group， 42 cases in each group.Patients in the control group were treated with Cisplatin combined with Capecitabine chemotherapy， patients in the observation group were treated on the basis of invigorating spleen and stomach and activating qi in the control group. The symptoms of abdominal discomfort， tasteless mouth and decreased appetite， the improvement of hemoglobin (Hb)， albumin (ALB) and total serum protein (TP) before and after treatment and clinical effect were compared between the two groups. Result： Before treatment， there were no significant differences in the scores of symptoms of epigastric discomfort， tasteless mouth and appetite loss between the two groups (P>0.05); after treatment， the scores of epigastric discomfort， tasteless mouth and appetite loss in both groups were higher than those before treatment， with significant differences (P<0.05)， and the scores of epigastric discomfort， tasteless mouth and appetite loss in the observation group were lower than those in the control group， with significant differences (P<0.05). There were no significant differences in the nutritional indexes of Hb， ALB and TP between the two groups before treatment (P>0.05); the nutritional indexes of Hb， ALB and TP in the two groups after treatment were lower than those before chemotherapy (P<0.05)， and the nutritional indexes of Hb， ALB and TP in the observation group after treatment were significantly higher than those in the control group， the differences were statistically significant (P<0.05). The total effective rate of the observation group was 76.19%， which was significantly higher than 54.76% of the control group， the difference was statistically significant (P<0.05). Conclusion： The effect of invigorating spleen and stomach on adverse reactions of digestive tract caused by chemotherapy for advanced gastrointestinal malignant tumors is remarkable， and can improve the effect of chemotherapy， which is worth popularizing., 百拇医药(谢明君 姜劼琳 葛来安)
【关键词】 健脾和胃行气法 消化道恶性肿瘤 化疗 消化道不良反应
Clinical Observation of Invigorating Spleen and Stomach for the Treatment of Adverse Reactions of Digestive Tract Caused by Chemotherapy for Advanced Malignant Tumor of Digestive Tract (Pixu Qizhi Type) /XIE Mingjun， JIANG Jielin， GE Lai’an. //Medical Innovation of China， 2019， 16(29)： 00-013
[Abstract] Objective： To explore the clinical efficacy of invigorating spleen and stomach for adverse reactions of digestive tract caused by chemotherapy for advanced malignant tumor of digestive tract. Method： From December 2014 to October 2017， 84 patients receiving chemotherapy intervention in our hospital due to advanced digestive tract malignant tumor (Pixu Qizhi Type) were included in the study. According to the random number table method， the patients were divided into the control group and the observation group， 42 cases in each group.Patients in the control group were treated with Cisplatin combined with Capecitabine chemotherapy， patients in the observation group were treated on the basis of invigorating spleen and stomach and activating qi in the control group. The symptoms of abdominal discomfort， tasteless mouth and decreased appetite， the improvement of hemoglobin (Hb)， albumin (ALB) and total serum protein (TP) before and after treatment and clinical effect were compared between the two groups. Result： Before treatment， there were no significant differences in the scores of symptoms of epigastric discomfort， tasteless mouth and appetite loss between the two groups (P>0.05); after treatment， the scores of epigastric discomfort， tasteless mouth and appetite loss in both groups were higher than those before treatment， with significant differences (P<0.05)， and the scores of epigastric discomfort， tasteless mouth and appetite loss in the observation group were lower than those in the control group， with significant differences (P<0.05). There were no significant differences in the nutritional indexes of Hb， ALB and TP between the two groups before treatment (P>0.05); the nutritional indexes of Hb， ALB and TP in the two groups after treatment were lower than those before chemotherapy (P<0.05)， and the nutritional indexes of Hb， ALB and TP in the observation group after treatment were significantly higher than those in the control group， the differences were statistically significant (P<0.05). The total effective rate of the observation group was 76.19%， which was significantly higher than 54.76% of the control group， the difference was statistically significant (P<0.05). Conclusion： The effect of invigorating spleen and stomach on adverse reactions of digestive tract caused by chemotherapy for advanced gastrointestinal malignant tumors is remarkable， and can improve the effect of chemotherapy， which is worth popularizing., 百拇医药(谢明君 姜劼琳 葛来安)