回顾分析174例FISH和IHC全自动平台检测HER-2基因的状态(2)
[Key words] Breast cancer HER-2 gene Fluorescence in situ hybridization Automated immunohistochemistryFirst-author’s address: Affiliated Cancer Hospital and Insititute of Guangzhou Medical University, Guangzhou 510095, China
doi:10.3969/j.issn.1674-4985.2019.29.006
乳腺癌给女性健康造成极大的威胁,发病率正逐年攀升,女性肿瘤排位是最常见的恶性肿瘤之一[1]。人类表皮生长因子受体2(humanepidermal growth factor receptor-2,HER-2)是一种原癌基因,此基因位点在于17号染色体的长臂上,其表达产物为是一种跨膜蛋白:C-erbB2,此蛋白具有酪氨酸激酶活性。肿瘤中C-erbB2过表达,提示分化低、恶性度高、预后差 ......
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