护患共同参与型护理模式对EGFRTKI获得性耐药晚期非小细胞肺癌患者的影响(1)
【摘要】 目的：探討护患共同参与型护理模式对EGFRTKI获得性耐药晚期非小细胞肺癌(NSCLC)患者的护理效果。方法：选取2018年12月-2019年8月本院收治的120例吉非替尼耐药晚期NSCLC患者为研究对象。将其随机分为干预组和对照组，每组60例。对照组实施常规护理，干预组实施护患共同参与型护理模式，比较两组患者肺癌相关症状、焦虑抑郁评分及患者满意度。结果：干预后，两组肺癌相关症状各项评分均下降，且干预组肺癌相关症状各项评分均低于对照组，差异均有统计学意义(P<0.05)。干预后，两组焦虑及抑郁评分均低于干预前，且干预组焦虑及抑郁评分均低于对照组，差异均有统计学意义(P<0.05)。干预组患者满意度评分明显高于对照组，差异有统计学意义(P<0.05)。结论：护患共同参与型护理模式促进EGFRTKI获得性耐药晚期NSCLC患者参与自我护理，改善肺癌相关症状，缓解不良情绪，提高患者满意度。
【关键词】 护患共同参与型护理模式 非小细胞肺癌 表皮生长因子受体酪氨酸激酶抑制剂 焦虑抑郁 满意度
[Abstract] Objective： To explore the nursing effect of nurse-patient participatory nursing mode on patients with advanced non-small cell lung cancer (NSCLC) with acquired drug resistance to EGFRTKI. Method： A total of 120 Gefitinib resistant advanced NSCLC patients admitted to our hospital from December 2018 to August 2019 were selected as study subjects. They were randomly divided into intervention group and control group， 60 cases in each group. The control group received routine nursing， the intervention group implemented the nurse-patient participatory nursing model. The lung cancer related symptoms， anxiety and depression scores and patients’ satisfaction were compared between the two groups. Result： After intervention， scores of lung cancer related symptoms in both groups decreased， and scores of lung cancer related symptoms in the intervention group were lower than those in the control group， with statistically significant differences (P<0.05). After intervention， scores of anxiety and depression in both groups were lower than those before intervention， and scores of anxiety and depression in the intervention group were lower than those in the control group， with statistically significant differences (P<0.05). The satisfaction scores of patients in the intervention group were significantly higher than those in the control group， the difference was statistically significant (P<0.05). Conclusion： The nurse-patient participatory nursing model promotes the participation of EGFRTKI resistant advanced NSCLC patients in self-care， improves lung cancer-related symptoms， alleviates bad mood， and improves patient satisfaction.
[Key words] Nurse-patient participatory nursing model Non-small cell lung cancer EGFR tyrosine kinase inhibitors Anxiety Depression Satisfaction
First-author’s address： Zhongshan People’s Hospital， Zhongshan 528400， China
doi：10.3969/j.issn.1674-4985.2020.19.028
非小细胞肺癌(non-small-cell lung cancer， NSCLC)是恶性肿瘤，大多数患者首次确诊时已属晚期，且5年生存率较低[1]。研究证实了表皮生长因子受体酪氨酸激酶抑制剂(EGFRTKI)靶向治疗表皮生长因子受体(EGFR)突变阳性晚期NSCLC患者效果明显，可延长无进展生存期[2]。以吉非替尼或厄洛替尼为代表的EGFRTKI治疗EGFR突变晚期NSCLC患者疗效显著，但治疗8～14个月后会出现获得性耐药，影响患者的生存[1-3]。化疗是治疗肺癌的有效方法，EGFRTKI联合化疗作为晚期NSCLC一线治疗，可提高疾病的缓解率和控制率，延缓疾病进展[4-5]。但化疗不良反应较多，部分患者难以忍受，导致治疗依从性低，影响治疗效果。为了提高肺癌患者的治疗效果，护理专家在不断探索新的护理模式[6]。护患共同参与型护理模式应用在临床中取得了较好的效果，但在晚期肺癌患者中应用较少[7-8]。本研究对EGFRTKI获得性耐药晚期NSCLC患者实施护患共同参与型护理模式，取得了较好的效果，现报道如下。, 百拇医药(吴春花 梁桂喜 陈鑫 杨姝妹)
【关键词】 护患共同参与型护理模式 非小细胞肺癌 表皮生长因子受体酪氨酸激酶抑制剂 焦虑抑郁 满意度
[Abstract] Objective： To explore the nursing effect of nurse-patient participatory nursing mode on patients with advanced non-small cell lung cancer (NSCLC) with acquired drug resistance to EGFRTKI. Method： A total of 120 Gefitinib resistant advanced NSCLC patients admitted to our hospital from December 2018 to August 2019 were selected as study subjects. They were randomly divided into intervention group and control group， 60 cases in each group. The control group received routine nursing， the intervention group implemented the nurse-patient participatory nursing model. The lung cancer related symptoms， anxiety and depression scores and patients’ satisfaction were compared between the two groups. Result： After intervention， scores of lung cancer related symptoms in both groups decreased， and scores of lung cancer related symptoms in the intervention group were lower than those in the control group， with statistically significant differences (P<0.05). After intervention， scores of anxiety and depression in both groups were lower than those before intervention， and scores of anxiety and depression in the intervention group were lower than those in the control group， with statistically significant differences (P<0.05). The satisfaction scores of patients in the intervention group were significantly higher than those in the control group， the difference was statistically significant (P<0.05). Conclusion： The nurse-patient participatory nursing model promotes the participation of EGFRTKI resistant advanced NSCLC patients in self-care， improves lung cancer-related symptoms， alleviates bad mood， and improves patient satisfaction.
[Key words] Nurse-patient participatory nursing model Non-small cell lung cancer EGFR tyrosine kinase inhibitors Anxiety Depression Satisfaction
First-author’s address： Zhongshan People’s Hospital， Zhongshan 528400， China
doi：10.3969/j.issn.1674-4985.2020.19.028
非小细胞肺癌(non-small-cell lung cancer， NSCLC)是恶性肿瘤，大多数患者首次确诊时已属晚期，且5年生存率较低[1]。研究证实了表皮生长因子受体酪氨酸激酶抑制剂(EGFRTKI)靶向治疗表皮生长因子受体(EGFR)突变阳性晚期NSCLC患者效果明显，可延长无进展生存期[2]。以吉非替尼或厄洛替尼为代表的EGFRTKI治疗EGFR突变晚期NSCLC患者疗效显著，但治疗8～14个月后会出现获得性耐药，影响患者的生存[1-3]。化疗是治疗肺癌的有效方法，EGFRTKI联合化疗作为晚期NSCLC一线治疗，可提高疾病的缓解率和控制率，延缓疾病进展[4-5]。但化疗不良反应较多，部分患者难以忍受，导致治疗依从性低，影响治疗效果。为了提高肺癌患者的治疗效果，护理专家在不断探索新的护理模式[6]。护患共同参与型护理模式应用在临床中取得了较好的效果，但在晚期肺癌患者中应用较少[7-8]。本研究对EGFRTKI获得性耐药晚期NSCLC患者实施护患共同参与型护理模式，取得了较好的效果，现报道如下。, 百拇医药(吴春花 梁桂喜 陈鑫 杨姝妹)