纤维支气管镜肺泡灌洗联合传统治疗对重症肺部感染患者肺功能及炎症因子的影响(1)
【摘要】 目的：研究纤维支气管镜肺泡灌洗联合传统治疗对重症肺部感染患者肺通气功能及血清中炎症因子的影响。方法：选取2017年12月-2018年12月于本院进行治疗的70例重症肺部感染患者为研究对象，采用随机数字表法将其分为对照组和试验组，每组35例。对照组患者给予传统治疗，试验组患者给予纤维支气管镜肺泡灌洗联合传统治疗。对比两组治疗效果及临床症状、肺通气功能、炎症因子改善情况。结果：试验组的总有效率为94.29%，高于对照组的77.14%(P<0.05)。试验组患者的咳嗽咳痰消失时间(9.66±2.40)d、感染控制時间(10.43±2.71)d与住院时间(13.46±3.57)d均短于对照组的(14.83±2.77)、(15.71±3.04)、(19.14±3.21)d(P<0.05)。治疗后，试验组的最大通气量(MVV)为(101.63±11.96)L/min、一秒钟用力呼气容积(FEV1)为(2 879.54±419.93)mL、最大呼气中段流量(MMF)为(3 074.14±398.19)mL/s均高于对照组的(90.83±12.48)L/min、(2 437.49±435.38)mL、(2 541.60±379.09)mL/s(P<0.05)。试验组C反应蛋白(CRP)(12.8±2.3)mg/L、肿瘤坏死因子(TNF-α)为(3.2±0.8)ng/L、白介素-6(IL-6)(122.7±26.3)ng/L、白介素-8(IL-8)(286.9±65.7)ng/L均低于对照组的(24.6±3.4)mg/L、(5.7±1.1)ng/L、(159.0±28.5)ng/L、(345.5±69.1)ng/L(P<0.05)。结论：对重症肺部感染患者进行纤维支气管镜肺泡灌洗联合传统治疗，能够取得较好的临床疗效，在改善患者肺通气功能、缓解炎症反应方面具有积极的作用。
【关键词】 纤维支气管镜 肺泡灌洗 重症肺部感染 肺通气功能 炎症因子
[Abstract] Objective： To study the effects of fiberoptic bronchoscopic alveolar lavage combined with traditional therapy on pulmonary ventilation function and inflammatory factors in patients with severe pulmonary infection. Method： A total of 70 patients with severe pulmonary infection admitted to our hospital from December 2017 to December 2018 were selected. They were divided into control group and experimental group by random number table method， 35 cases in each group. The patients in the control group were given traditional therapy， while the patients in the experimental group were given fiberoptic bronchoscopic alveolar lavage combined with traditional therapy. The effective， clinical symptoms， pulmonary ventilation function and inflammatory factors were compared between the two groups. Result： The total effective rate in the experimental group was 94.29%， higher than 77.14% in the control group (P<0.05). The cough and sputum disappearance time (9.66±2.40) d， infection control time (10.43±2.71) d and hospitalization time (13.46±3.57) d of the experimental group were shorter than (14.83±2.77)， (15.71±3.04)， (19.14±3.21) d of the control group (P<0.05). After treatment， the maximum ventilation volume (MVV) (101.63±11.96) L/min， forced expiratory volume in one second (FEV1) (2 879.54±419.93) mL and maximum midexpiratory flow (MMF) (3 074.14±398.19) mL/s of the experimental group were higher than (90.83±12.48) L/min， (2 437.49±435.38) mL， (2 541.60±379.09) mL/s of the control group (P<0.05). The levels of C-reactive protein (CRP) (12.8±2.3) mg/L， tumor necrosis factor-α (TNF-α) (3.2±0.8) ng/L， interleukin-6 (IL-6) (122.7±26.3) ng/L and interleukin-8 (IL-8) (286.9±65.7) ng/L in the experimental group were lower than (24.6±3.4) mg/L， (5.7±1.1) ng/L， (159.0±28.5) ng/L， (345.5±69.1) ng/L in the control group (P<0.05). Conclusion： The combination of fiberoptic bronchoscopic alveolar lavage and traditional therapy for patients with severe pulmonary infection has a good clinical effect， which could improve the pulmonary ventilation function and reduce inflammatory reaction., http://www.100md.com(程耀强 黄卢清 陀子能)
【关键词】 纤维支气管镜 肺泡灌洗 重症肺部感染 肺通气功能 炎症因子
[Abstract] Objective： To study the effects of fiberoptic bronchoscopic alveolar lavage combined with traditional therapy on pulmonary ventilation function and inflammatory factors in patients with severe pulmonary infection. Method： A total of 70 patients with severe pulmonary infection admitted to our hospital from December 2017 to December 2018 were selected. They were divided into control group and experimental group by random number table method， 35 cases in each group. The patients in the control group were given traditional therapy， while the patients in the experimental group were given fiberoptic bronchoscopic alveolar lavage combined with traditional therapy. The effective， clinical symptoms， pulmonary ventilation function and inflammatory factors were compared between the two groups. Result： The total effective rate in the experimental group was 94.29%， higher than 77.14% in the control group (P<0.05). The cough and sputum disappearance time (9.66±2.40) d， infection control time (10.43±2.71) d and hospitalization time (13.46±3.57) d of the experimental group were shorter than (14.83±2.77)， (15.71±3.04)， (19.14±3.21) d of the control group (P<0.05). After treatment， the maximum ventilation volume (MVV) (101.63±11.96) L/min， forced expiratory volume in one second (FEV1) (2 879.54±419.93) mL and maximum midexpiratory flow (MMF) (3 074.14±398.19) mL/s of the experimental group were higher than (90.83±12.48) L/min， (2 437.49±435.38) mL， (2 541.60±379.09) mL/s of the control group (P<0.05). The levels of C-reactive protein (CRP) (12.8±2.3) mg/L， tumor necrosis factor-α (TNF-α) (3.2±0.8) ng/L， interleukin-6 (IL-6) (122.7±26.3) ng/L and interleukin-8 (IL-8) (286.9±65.7) ng/L in the experimental group were lower than (24.6±3.4) mg/L， (5.7±1.1) ng/L， (159.0±28.5) ng/L， (345.5±69.1) ng/L in the control group (P<0.05). Conclusion： The combination of fiberoptic bronchoscopic alveolar lavage and traditional therapy for patients with severe pulmonary infection has a good clinical effect， which could improve the pulmonary ventilation function and reduce inflammatory reaction., http://www.100md.com(程耀强 黄卢清 陀子能)