increased the expression of HOXB8， with statistically significant differences compared with the negative control group (P<0.05). Conclusion： HPV18 may down-regulate the expression of miR-24-3p through DNA methylation and histone methylation， leading to increased HOXB8 expression， and then promote the occurrence and development of cervical cancer. It provides experimental basis and intervention targets for the treatment of HPV18+ cervical cancer.

    [Key words] HPV18 Cervical cancer miR-24-3p HOXB8 DNA methylation H3K27me3

    First-author’s address： Hongqi Hospital Affiliated of Mudanjiang Medical College ......