毛瑞昭 刘盼 谭胜 连长红

    【摘要】 胃肠道间质瘤(gastrointestinal stromal tumor，GIST)可累及胃肠道任意部位，其临床表现不明显且无特异性，早期诊断相对困难。随着GIST体积增大，术前相关辅助检查可帮助明确诊断。一方面，近年来消化内镜和影像技术的飞速发展对GIST早期检出率的提高具有极其重要的作用;另一方面，随着人们对GIST发病机制的不断探究，以伊马替尼为代表的分子靶向药物正普遍应用于GIST的临床治疗，与更智能、前沿的医疗器械一同推动着外科手术的改变和进步。本文就GIST的术前诊断及其治疗进展进行了综述。

    【关键词】 胃肠道间质瘤 术前诊断 手术 靶向药物

    [Abstract] Gastrointestinal stromal tumor (GIST) can involve any part of the gastrointestinal tract， its clinical manifestations are not obvious and specific， making early diagnosis relatively difficult. As GIST increases in size， preoperative relevant auxiliary examinations can help make a definite diagnosis. On the one hand， the rapid development of digestive endoscopy and imaging technology has played an extremely important role in improving the detection rate of GIST at the early stage in recent years; on the other hand， as people continue to explore the pathogenesis of GIST， molecular targeted drugs represented by Imatinib are widely used in the clinical treatment of GIST， together with more intelligent and cutting-edge medical instruments to promote the changes and progress of surgery. This article reviewed the preoperative diagnosis and treatment of GIST. ......