杨翠英 谭云波 陈奕明

    【摘要】 胃癌严重影响人们的生存和生活质量，研究表明2型糖尿病与胃癌关系密切，两者相互促进，但相关发病机制尚不十分明确。多项研究证实了自噬在胃癌与2型糖尿病两种疾病中普遍呈高表达，并且在两种疾病的病理生理过程中均发挥了重要作用，但是作用机制尚不清楚。本文就自噬、胃癌与2型糖尿病三者之间的关系进行文献回顾，认为自噬可能是2型糖尿病与胃癌相互促进的机制之一。

    【关键词】 自噬 胃癌 2型糖尿病

    [Abstract] Gastric cancer seriously affects peoples survival and quality of life. Studies have shown that there is a close relationship between type 2 diabetes and gastric cancer， and the two promote each other， but the related pathogenesis is still not very clear. A number of studies have confirmed that autophagy is generally highly expressed in gastric cancer and type 2 diabetes， and plays an important role in the pathophysiological processes of both diseases， but the mechanism remains unclear. In this paper， the relationship among autophagy， gastric cancer and type 2 diabetes was reviewed in the literature， suggested that autophagy may be one of the mechanisms by which type 2 diabetes and gastric cancer promote each other.

    [Key words] Autophagy Gastric cancer Type 2 diabetes

    First-authors address： Clinical College of Dali University， Dali 671000 ......