刘景晨 李蕾 徐兵 孙曙光

    【摘要】 缺氧是中晚期视网膜母细胞瘤(retinoblastoma，RB)发生率非常高的微环境改变，缺氧调节的主要因子低氧诱导因子-1α(Hypoxia inducible factors-1α，HIF-1α)在RB的肿瘤生物学方面发挥着关键作用。因此，HIF-1α在RB肿瘤生物学中的作用研究是开发新的抗RB药物及治疗的重点所在，本文对HIF-1α在RB肿瘤生物学方面的作用及基于HIF-1α抗RB研究的方面做一综述，为RB的治疗寻找新的方向。

    【关键词】 缺氧诱导因子-1α 视网膜母细胞瘤 肿瘤生物学 化疗

    [Abstract] Hypoxia is a very high incidence of microenvironmental changes in advanced retinoblastoma(RB). Hypoxia-inducible factor-1α(HIF-1α)， the key factor in the regulation of hypoxia microenvironment， plays a key role in retinoblastoma cell proliferation，tumor metastasis， tumor angiogenesis， drug resistance generation and differentiation of tumor stem cells. Therefore， the study on the role of HIF-1α in RB tumor biology is the focus of the development of new anti-rb drugs and treatments. In this paper， the biological role of HIF-1α in RB tumor and the anti-RB research based on HIF-1α were reviewed， so as to find a new direction for the treatment of RB.

    [Key words] Hypoxia inducible factors-1α Retinoblastoma Tumor biology chemotherapy

    视网膜母细胞瘤(Retinoblastoma，RB)是5岁以下的儿童眼部发病率最高的恶性肿瘤，在全球范围内该病的发病率为1/15 000～1/20 000 ......