金莲锦 胡春阳 李罡 刘岩 李琳 温立勇

    【摘要】 目的：观察右美托咪定(Dex)对心肌缺血再灌注损伤大鼠心肌功能、炎症反应及HMGB1/TLR4/NF-κB信号通路的影响。方法：取75只成年SPF级10周龄雄性SD大鼠。运用可复性结扎LAD法建立心肌缺血再灌注损伤(MIRI)模型。随机均分为假手术组(Sham组)、Dex预处理+MIRI组(Dex组)、Dex+育亨宾+MIRI组(Dex/Yoh组)、育亨宾预处理+MIRI组(Yoh组)与MIRI组(I/R组)，每组15只。比较各组心肌梗死面积(IS/AAR)。运用ELISA检测并比较各组心肌组织与血清TNF-α、IL-6水平。采用 Western blot检测并比较心肌组织HMGB1、TLR-4、MyD88、NF-κB蛋白表达情况。结果：Dex组、Dex/Yoh组、Yoh组及I/R组心肌组织与血清TNF-α、IL-6水平均高于Sham组，其中Dex组
    【关键词】 右美托咪定 HMGB1/TLR4/NF-κB信号通路 心肌缺血再灌注损伤

    [Abstract] Objective： To observe the effects of Dexmedetomidine (Dex) on myocardial function， inflammatory response and HMGB1/TLR4/NF-κB signaling pathway in rats with myocardial ischemia-reperfusion injury. Method： A total of 75 adult SPF 10-week-old male SD rats were selected. The model of myocardial ischemia reperfusion injury (MIRI) was established by using the repeatable ligation LAD method. They were randomly divided into Sham operation group (Sham group) ......

    百拇医药网 http://www.100md.com/html/paper/1674-4985/2021/09/007.htm

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