方宁 林彩战

    【摘要】 目的：探讨二肽基肽酶-4(DPP-4)抑制剂在2型糖尿病(T2DM)合并非酒精性脂肪肝(NAFLD)患者中的应用效果。方法：选取2018年1月-2019年2月在本院治疗的T2DM合并NAFLD患者164例，根据治疗方案分为观察组(n=88)和对照组(n=76)。对照组给予常规治疗，观察组在对照组基础上加用DPP-4抑制剂，观察两组治疗效果。结果：治疗后，两组丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)和谷氨酰胺转肽酶(GGT)均较治疗前改善(P0.05)。结论：DPP-4抑制剂治疗T2DM合并NAFLD中有较好的效果，能明显改善患者肝功能、血脂及血糖水平。

    【关键词】 二肽基肽酶-4抑制剂 2型糖尿病 非酒精性脂肪肝

    [Abstract] Objective： To investigate the clinical effect of dipeptidyl peptidase-4 (DPP-4) inhibitor in type 2 diabetes mellitus (T2DM) with nonalcoholic fatty liver disease (NAFLD). Method： A total of 164 patients with T2DM complicated with NAFLD who treated in our hospital from January 2018 to February 2019 were selected. According to the treatment plan， they were divided into observation group (n=88) and control group (n=76). The control group was given routine treatment， and the observation group was added with DPP-4 inhibitor on the basis of the control group， the treatment effects of two groups were observed. Result： After treatment ......