石奇嵩

    【摘要】 目的：探讨文拉法辛联合喹硫平治疗重度抑郁症急性期患者的效果及对血清BDNF、Cor表达的影响。方法：选取自2019年3月-2020年4月本院收治的68例重度抑郁症急性期患者，按照随机数字表法分为两组，各34例。对照组给予文拉法辛治疗，观察组给予文拉法辛联合喹硫平。比较两组治疗前后抑郁状态评分、血清BDNF与Cor表达水平及不良反应发生情况。结果：治疗后，两组MADRS评分、HAMD-17评分均低于治疗前，且观察组均低于对照组(P0.05)。结论：文拉法辛联合喹硫平治疗可明显减轻重度抑郁症急性期患者的抑郁状态，并可上调血清BDNF表达，下调Cor表达，安全有效。

    【关键词】 文拉法辛 喹硫平 重度抑郁症 急性期 皮质醇

    Effect of Venlafaxine Combined with Quetiapine in the Treatment of Acute Stage of Major Depression and Its Effect on the Expression of Serum BDNF and Cor/SHI Qisong. //Medical Innovation of China， 2021， 18(13)： -142

    [Abstract] Objective： To investigate the effect of Venlafaxine combined with Quetiapine in the treatment of acute phase of major depression patients and its effect on the expression of serum BDNF and Cor. Method： A total of 68 patients with acute phase of major depression were selected from March 2019 to April 2020 ......