刘人杰

    【摘要】 目的：探討索拉菲尼治疗原发性肝癌(PLC)的效果及对患者血清热休克蛋白90α(HSP90α)、血管内皮生长因子(VEGF)水平的影响。方法：选取2018年1-12月本院收治的不可手术切除的PLC患者63例为观察对象。按照治疗方式分为对照组(n=31)和观察组(n=32)。对照组采用肝动脉化疗栓塞术(TACE)治疗，观察组在TACE基础上口服索拉菲尼治疗。比较两组疗效、瘤体体积、血清HSP90α、VEGF、安全性、生存情况、总生存期。结果：两组ORR比较，差异无统计学意义(P>0.05);观察组DCR为81.25%，高于对照组的58.06%，差异有统计学意义(P0.05);观察组高血压、皮肤黏膜反应发生率均高于对照组，差异均有统计学意义(P0.05). The DCR of the observation group was 81.25%， higher than 58.06% of the control group， the difference was statistically significant (P0.05). The incidence of hypertension and skin mucosal reaction in the observation group was higher than that in the control group ......