王宇航 王为光 赵悦荣 杜美霖

    【摘要】 白细胞介素17(interleukin 17，IL-17)是由辅助性T细胞17(helper T cell 17，Th17)分泌具有细胞因子性质的蛋白，白细胞介素35(interleukin 35，IL-35)是IL-12家族的新成员可抑制Th17的分化及IL-17的分泌，从而发挥免疫抑制作用。目前研究认为，IL-17和IL-35参与人类各系统疾病的发生、发展，并将与各类疾病的关系进行综述。

    【关键词】 白细胞介素17 白细胞介素35 自身免疫 肿瘤

    Research Progress between IL-17 and IL-35 and Various Diseases/WANG Yuhang， WANG Weiguang， ZHAO Yuerong， DU Meilin. //Medical Innovation of China， 2021， 18(14)： -184

    [Abstract] Interleukin 17 (IL-17) is a protein with cytokine properties secreted by T helper cell (Th17)， interleukin 35 (IL-35) is a new member of the IL-12 family and can inhibit the differentiation of Th17 and the secretion of IL-17， thereby exerting an immunosuppressive effect. Current research believes that IL-17 and IL-35 are involved in the occurrence and development of various human diseases， and the relationship with various diseases will be reviewed.

    [Key words] Interleukin 17 Interleukin 35 Self-immune Tumor

    First-authors address： The First Affiliated Hospital of Jiamusi University， Jiamusi 154000， China

    doi：10.3969/j.issn.1674-4985.2021.14.043 ......