郭鑫 吴飞飞

    【摘要】 2型糖尿病(type 2 diabetes mellitus，T2DM)是常见疾病，随着患病率不断上升，其慢性并发症也给患者的生活、家庭以及社会带来了沉重的负担。糖尿病肾病是糖尿病常见的严重并发症之一，现已成为终末期肾衰的主要原因，而且缺乏有效的治疗手段，目前主要以降糖、降压、调脂为主，但是传统的治疗方法并不能阻止糖尿病肾病进展，因此有必要探索新的研究方向以期早发现早预防。目前人体内肠道菌群多样性、组成及其代谢和免疫特性与2型糖尿病的发生成为关注的研究热点。本文总结了肠道菌群参与糖尿病肾病发生的相关致病机制。

    【关键词】 肠道菌群 2型糖尿病 糖尿病肾病 粪便菌群移植

    The Research Progress of Intestinal Flora in the Pathogenesis of Diabetic Nephropathy/GUO Xin， WU Feifei. //Medical Innovation of China， 2021， 18(14)： -188

    [Abstract] Type 2 diabetes mellitus (T2DM) is a common disease. As the prevalence rate continues to rise， its chronic complications also put a heavy burden on the patients own life， family and society. Diabetic nephropathy is one of the common serious complications of diabetes， and it has become the main cause of end-stage renal failure， and there is a lack of effective treatment. At present， the main treatment methods are hypoglycemic， hypotensive， and lipid-lowering， but traditional treatment methods can not prevent the progress of diabetic nephropathy， so it is necessary to explore new research directions with a view to early detection and early prevention. Now ......