姜如海

    【摘要】 目的：探究丁苯酞對急性脑梗死患者血液黏度及趋化因子的影响。方法：选取2018年10月-2020年6月98例急性脑梗死患者，根据随机数字表法将其分为对照组和观察组，每组50例。对照组进行常规脑梗死治疗，观察组则在对照组的基础上加用丁苯酞。比较两组疗效、治疗前后的全血黏度、全血还原黏度及血清趋化因子(CXCL4、CXCL12、CXCL16)。结果：观察组总有效率高于对照组，差异有统计学意义(P<0.05)。治疗前，两组的全血高切黏度、全血中切黏度、全血低切黏度、全血高切还原黏度、全血中切还原黏度、全血低切还原黏度、CXCL4、CXCL12、CXCL16比较，差异均无统计学意义(P>0.05);治疗1、2周后，两组的全血高切黏度、全血中切黏度、全血低切黏度、全血高切还原黏度、全血中切还原黏度、全血低切还原黏度、CXCL4、CXCL12、CXCL16均低于治疗前，且观察组均低于对照组，差异均有统计学意义(P<0.05)。结论：丁苯酞在急性脑梗死患者中的应用效果较好，且可改善患者的血液黏度及趋化因子，在急性脑梗死患者中的应用价值较高。

    【关键词】 丁苯酞 急性脑梗死 血液黏度 趋化因子

    [Abstract] Objective： To investigate the influence of Butylphthalide for blood viscosity and chemokines in patients with acute cerebral infarction. Method： A total of 98 patients with acute cerebral infarction from October 2018 to June 2020 were selected， and they were divided into control group and observation group according to the method of random number table， 50 cases in each group. The control group was treated with routine treatment for cerebral infarction， the observation group was treated with Butylphthalide on the treatment of control group. The efficacy was compared between two groups ......