高红梅 黄新梅 曹文琼 陈立军 哈华兰 陆敬雁 朱学新 贾新燕

    【关键词】 高尿酸血症 高尿酸血症性肾病 NLRP3 IL-1β TNF-α

    [Abstract] Objective： To detect the level of NLRP3/IL-1β signaling pathway in patients with hyperuric acid nephropathy，to explore its role in hyperuric acid nephropathy. Method： A total of 42 patients with hyperuricemia and 26 patients with hyperuricemic nephropathy admitted to our hospital from September 2018 to September 2020 were selected， and 35 healthy people who underwent physical examination during the same period were selected as the healthy control group. Peripheral blood monocytes were isolated， the mRNA levels of NLRP3 and caspase-1 were detected by real-time fluorescence quantitative PCR ......