刘杰 陈佳琦 严旺

    【摘要】 帕金森病是继阿尔茨海默病之后第二大常见的神经退行性疾病，近年来帕金森病合并周围神经损害也越来越多地受到人们的关注。左旋多巴是治疗帕金森病的主要药物，多项研究表示口服左旋多巴可导致帕金森病周围神经病变发病率升高，但其发病机制尚不明确。本文从流行病学、发病机制、病理、临床表现、神经电生理、治疗方面论述左旋多巴与帕金森病周围神经病变的研究进展，为帕金森病周围神经病变治疗提供思路。

    【关键词】 帕金森病 左旋多巴 周围神经系统疾病

    Research Progress of Levodopa and Neuropathy in Parkinson Disease/LIU Jie， CHEN Jiaqi， YAN Wang. //Medical Innovation of China， 2021， 18(32)： -185

    [Abstract] Parkinson disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease. In recent years， peripheral neuropathy (PNP) in patients with PD has attracted more and more attention. Levodopa is the main drug in the treatment of PD， however， several studies have shown that an increased prevalence of peripheral neuropathy (PN) in patients with PD and long history of Levodopa exposure， but its pathogenesis is still unclear. In this paper， the research elucidates the relationship between Levodopa and neuropathy in PD from epidemiology， pathogenesis， pathology， clinical manifestation， neuroelectrophysiology and treatment， providing reference for exploring new treatment strategies of neuropathy in PD. ......