肖婷 黄小红

    【摘要】 目的：分析脑小血管病(CSVD)患者认知功能与尿酸(UA)、同型半胱氨酸(Hcy)水平的相关性。方法：选取本院2018年2月-2021年3月收治的109例CSVD患者，于患者入院时，采用蒙特利尔认知评估量表(MoCA)评估其认知功能情况，并分为认知功能障碍组与认知功能正常组;检测患者血清UA、Hcy水平及相关指标，并采集相关基线资料，重点分析CSVD患者认知功能与UA、Hcy水平的相关性。结果：109例CSVD患者经过MoCA评估，认知功能障碍患者59例，平均MoCA评分为(24.52±1.31)分;认知功能正常患者50例，平均MoCA评分为(28.03±1.35)分。认知功能障碍组UA、Hcy水平均高于认知功能正常组，差异均有统计学意义(P<0.05);两组其他基线资料、相关指标水平比较，差异均无统计学意义(P>0.05)。经Pearson相关性分析显示，CSVD患者MoCA评分与UA、Hcy水平均呈负相关(r=-0.716、-0.735，P<0.05)。结论：CSVD患者认知功能障碍与UA、Hcy水平升高有关。

    【关键词】 脑小血管病 认知功能 尿酸 同型半胱氨酸 相关性

    Correlation between Cognitive Function and Uric Acid and Homocysteine Levels in Patients with Small Cerebral Vascular Disease/XIAO Ting， HUANG Xiaohong. //Medical Innovation of China， 2021， 18(35)： 072-075

    [Abstract] Objective： To analyze the relationship between cognitive function and uric acid (UA) and homocysteine (Hcy) levels in patients with cerebral small vascular disease (CSVD). Method： A total of 109 patients with CSVD admitted to our hospital from February 2018 to March 2021 were selected， their cognitive function was assessed by Montreal Cognitive Assessment Scale (MoCA) on admission and they were divided into cognitive impairment group and normal cognitive function group. Serum UA and Hcy levels and related indicators were detected ......