李晓燕

    【摘要】 目的：探析曲美他嗪聯合胺碘酮治疗老年高血压心脏病的效果及对心肌重构的影响。方法：选取2015年1月-2022年1月荣成市人民医院收治的老年高血压心脏病患者120例，使用随机数字表法将其分为观察组及对照组，各60例。对照组行胺碘酮治疗，观察组在对照组基础上加用曲美他嗪，对比两组炎症因子指标、心肌重构指标、氧化应激指标及血管活性指标。结果：治疗前，两组白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、基质金属蛋白酶-3(MMP-3)及单核细胞p38丝裂原激活蛋白激酶(p38 MAPK)mRNA比较，差异均无统计学意义(P>0.05)；治疗3个月后，两组的指标均下降，观察组均低于对照组(P0.05)；治疗3个月后，两组LVEF均上升，观察组高于对照组(P0.05)；治疗3个月后，两组的SOD及GSH-Px均上升，观察组均高于对照组(P0.05)；治疗3个月后，两组的NO及6-Keto-PGF1α均上升，观察组高于对照组(P0.05); after 3 months of treatment， the indexes in both groups decreased， the observation group were lower than those of the control group (P0.05); after 3 months of treatment， LVEF increased in both groups， the observation group was higher than that of the control group (P0.05); after 3 months of treatment， SOD and GSH-Px increased in both groups， the observation group were higher than those of the control group (P0.05); after 3 months of treatment ......