欧阳彦兰

    【摘要】 目的：探讨戊酸雌二醇预处理联合宫腔镜手术在治疗中重度宫腔粘连的临床应用。方法：前瞻性选取惠州市第一妇幼保健院2021年3月-2022年1月收治的56例中重度宫腔粘连患者，按照随机数字表法分为常规组和联合组，每组28例。两组均接受宫腔镜手术治疗，常规组在术后予以戊酸雌二醇治疗，联合组在常规组基础上予以戊酸雌二醇预处理治疗，观察两组患者子宫形态恢复情况、子宫内膜血流、细胞因子水平、月经恢复正常时间及宫腔再粘连发生率。结果：术前，两组子宫内膜厚度及子宫体积对比，差异均无统计学意义(P>0.05)；治疗结束后，两组子宫内膜厚度、体积均较术前增加，且联合组均高于常规组(P0.05)；治疗结束后，两组RI、PI均较术前下降，且联合组均低于常规组，两组VI、FI均较术前上升，且联合组均高于常规组(P0.05)；治疗结束后，两组TGF-β1、VEGF及MMP-9均较术前下降，且联合组均低于常规组。术后3个月，联合组宫腔粘连再发生率(7.14%)低于常规组(28.57%)(P0.05); after treatment， the endometrial thickness and volume of the two groups increased， and the combined group was higher than conventional group (P0.05); after treatment， RI and PI of both groups were decreased and the combined group was lower than the conventional group， VI and FI of both groups were increased and the combination group was higher than the conventional group (P0.05); after treatment ......