【摘要】 新生儿非获得性溶血性疾病是新生儿期常见的疾病，其病因复杂多样，又因临床表现及极其相近故常导致漏诊或者误诊。主要是由红细胞先天性缺陷，包括红细胞酶缺陷、红细胞形态异常、血红蛋白病、新生儿溶血病引起的溶血性疾病。本文综述了这几方面在新生儿非获得性溶血性疾病发病原因及机制的研究进展。

    【关键词】 非获得性溶血性疾病 新生儿 红细胞先天性缺陷

    Research Progress in the Pathogenesis of Non-acquired Hemolytic Disease of Newborn/CHANG Chao， LYU Yihua， BI Huiwen. //Medical Innovation of China， 2023， 20(17)： -188

    [Abstract] Non-acquired hemolytic disease of newborn is a common disease in neonatal period， its etiology is complex and diverse， and it often leads to missed diagnosis or misdiagnosis due to its similar clinical manifestations. It is mainly hemolytic disease caused by congenital defects of red blood cells， including enzyme defects of red blood cells， morphological abnormalities of red blood cells， hemoglobin disease and hemolytic disease of newborn. This article reviews the research progress in the pathogenesis of non-acquired hemolytic diseases in newborns.

    [Key words] Non-acquired hemolytic disease Newborn Congenital defects of red blood cells

    First-author's address： Jinan Maternal and Child Health Hospital Affiliated to Shandong First Medical University ......