陈伟鸿 苏小苹 苏宇超 黄栋钦 许永鹏

    【摘要】 结直肠癌(colorectal cancer，CRC)是全球第三大常见癌症，传统治疗方案对CRC晚期患者的疗效不佳，因此，发现新的治疗策略可能有助于改善CRC患者的治疗和预后。铁死亡是一种铁依赖型调节性细胞死亡，其特征是铁水平和活性氧(reactive oxygen species，ROS)的增加。CRC细胞存在高铁水平和高ROS水平，诱导发生铁死亡可能成为CRC新的治疗方法。本文综述了目前关于铁死亡机制的研究进展，介绍目前最新铁死亡诱导剂，包括小分子化合物以及纳米颗粒，为CRC开发新的治疗方案提供思路。

    【关键词】 结直肠癌 铁死亡 小分子化合物 纳米颗粒

    Research Progress of Ferroptosis Inducers in Colorectal Cancer/CHEN Weihong， SU Xiaoping， SU Yuchao， HUANG Dongqin， XU Yongpeng. //Medical Innovation of China， 2023， 20(34)： -184

    [Abstract] Colorectal cancer (CRC) is the third most common cancer in the world， and traditional treatment programs have poor efficacy in patients with advanced CRC. Therefore， novel therapeutic strategies may be helpful to improve the treatment and prognosis of CRC patients. Ferroptosis is an iron-dependent regulatory cell death characterized by the increase of iron and reactive oxygen species (ROS). CRC cells have high levels of iron and ROS， and inducing ferroptosis may become a new treatment method for CRC. This paper reviews the current research progress on the mechanism of ferroptosis and introduces the latest inducers of ferroptosis ......