阮涛 刘苗苗 霍岩松 宋立

    【摘要】 目的：探討TEC化疗方案联合保乳术在Ⅱ、Ⅲ期乳腺癌患者治疗中的可行性及对生存质量的影响。方法：选取2018年2月—2020年2月济宁市第三人民医院收治的Ⅱ、Ⅲ期乳腺癌患者172例，依据随机数字表法分为对照组(86例，常规改良根治术)、观察组(86例，TEC化疗方案联合保乳术治疗)。观察组治疗3个月后对两组进行随访。比较两组随访期间的治疗效果，治疗前及治疗3个月后血清癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原153(CA153)、糖类抗原19-9(CA19-9)水平、生存质量评分，随访期间复发率、远处转移率、不良反应总发生率。结果：与治疗前比，治疗3个月后两组血清CEA、CA125、CA153、CA19-9水平均降低，观察组均低于对照组，差异均有统计学意义(P0.05)。结论：TEC化疗方案联合保乳术可以抑制Ⅱ、Ⅲ期乳腺癌患者的肿瘤细胞增殖，改善患者生存质量，且并发症发生率较低。

    【关键词】 乳腺癌 化疗 保乳术

    Feasibility of TEC Chemotherapy Combined with Breast-conserving Surgery in the Treatment of Patients with Stage Ⅱ and Ⅲ Breast Cancer/RUAN Tao， LIU Miaomiao， HUO Yansong， SONG Li. //Medical Innovation of China， 2024， 21(02)： 0-044

    [Abstract] Objective： To investigate the feasibility of TEC chemotherapy combined with breast-conserving surgery in the treatment of patients with stage Ⅱ and Ⅲ breast cancer and its effect on quality of life. Method： A total of 172 patients with stage Ⅱ and Ⅲ breast cancer admitted to Jining Third People's Hospital from February 2018 to February 2020 were selected and divided into the control group (86 cases ......