刘清玉 王蕾

    【摘要】 目的：探討多囊卵巢综合征患者采用小剂量阿司匹林与来曲唑联合治疗的临床效果。方法：选择78例于2020年1月—2022年4月在厦门大学附属第一医院接受治疗的多囊卵巢综合征患者，按照随机数字表法分为口服来曲唑的对照组39例及口服小剂量阿司匹林与来曲唑的观察组39例。均治疗3个月经周期。对比两组卵巢血流、血清性激素水平、排卵及妊娠情况(治疗结束后3、6个月对患者进行随访)、不良反应。结果：观察组治疗后卵巢的搏动指数(PI)、舒张末期流速(EDV)均较对照组低，收缩期峰值流速(PSV)较对照组高(P0.05)；随访3、6个月，观察组排卵率、妊娠率均较对照组高(P0.05)。结论：针对多囊卵巢综合征患者采取小剂量阿司匹林与来曲唑的联合用药方案，能够有效改善卵巢血流运行，提升排卵及妊娠率，且两者合用安全性高，但对性激素水平无明显调节作用。

    【关键词】 多囊卵巢综合征 阿司匹林 来曲唑 卵巢血流 血清性激素 排卵率 妊娠率

    Effects of Low-dose Aspirin Combined with Letrozole on Ovarian Blood Flow and Serum Sex Hormones in Patients with Polycystic Ovary Syndrome/LIU Qingyu， WANG Lei. //Medical Innovation of China， 2024， 21(02)： -141

    [Abstract] Objective： To investigate the clinical effect of low dose Aspirin combined with Letrozole in patients with polycystic ovary syndrome. Method： A total of 78 patients with polycystic ovary syndrome who received treatment in the First Affiliated Hospital of Xiamen University from January 2020 to April 2022 were selected and divided into the control group (39 cases) with oral Letrozole and the observation group (39 cases) with oral low-dose Aspirin and Letrozole according to random number table method. All patients were treated for 3 menstrual cycles. The ovarian blood flow ......