李薇 谭丽华 方兴

    【摘要】 血管性认知障碍(VCI)是指由脑血管病变及其危险因素引起的一类临床综合征，表现为不同程度的认知功能障碍。在近年来大量研究中显示，作为脑血管病密切相关的独立危险因素-高同型半胱氨酸血症(HHcy)，与VCI的发生发展可能有直接或间接的联系，本文的目的是将HHcy与VCI关系的新进展做一综述，为VCI的防治提供思路。

    【关键词】 高同型半胱氨酸血症 血管性认知障碍 发病机制

    Research Progress on the Correlation between Hyperhomocysteinemia and Vascular Cognitive Impairment/LI Wei， TAN Lihua， FANG Xing. //Medical Innovation of China， 2024， 21(02)： -188

    [Abstract] Vascular cognitive impairment (VCI) is a kind of clinical syndrome caused by cerebrovascular disease and its risk factors， which is manifested by different degrees of cognitive dysfunction. As an independent risk factor closely related to cerebrovascular disease， hyperhomocysteinemia (HHcy) has been shown in numerous studies in recent years to be directly or indirectly related to the occurrence and development of VCI. The purpose of this paper is to review the new progress in the relationship between HHcy and VCI， to provide ideas for the prevention and treatment of VCI.

    [Key words] Hyperhomocysteinemia Vascular cognitive impairment Pathogenesis

    First-author's address： Ruikang Clinical Medical College ......