李芃菲 肖敏 马雪娇 严兴科 马重兵

    【摘要】 抑郁症是由多种原因导致的精神疾病，其发病机制尚未完全明确。本文从脑功能和结构角度总结抑郁症的发病机制，发现抑郁症与海马、前额叶等脑区密切相关，海马及前额叶皮质面积、体积减小，神经元形态及超微结构损害是抑郁症的解剖和结构基础，血流减少、代谢降低、大脑网络连接异常、神经电生理活动失衡是抑郁症的脑功能机制。

    【关键词】 抑郁症 神经元 功能连接 结构连接 神经电生理

    Research Progress on Brain Function Mechanism of Onset of Depressive Disorder/LI Pengfei， XIAO Min， MA Xuejiao， YAN Xingke， MA Chongbing. //Medical Innovation of China， 2024， 21(05)： -169

    [Abstract] Depressive disorder is a mental disease caused by many reasons， and its pathogenesis has not been fully defined. This paper summarizes the pathogenesis of depression disorder from the perspective of brain function and structure， and finds that depression disorder is closely related to brain regions such as hippocampus and prefrontal cortex. The decrease in the area and volume of hippocampus and prefrontal cortex and the damage of neuronal morphology and ultrastructure are the anatomical and structural basis of depression disorder. Decreased blood flow， decreased metabolism， abnormal brain network connectivity and imbalance of neuroelectrophysiological activity are the brain functional mechanisms of depression disorder. ......