施振友 鲍国鸿

    【摘要】 目的：探討无创正压通气(NIPPV)联合盐酸氨溴索灌洗对急性呼吸衰竭(ARF)患者血气分析及炎症指标的影响。方法：选取宜春市中医院2021年4月—2023年3月收治的94例ARF患者，按随机数字表法分为对照组(47例)与研究组(47例)。对照组予NIPPV治疗，研究组基于对照组予盐酸氨溴索灌洗治疗。对比两组血气分析指标[血氧饱和度(SaO2)、动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)]、炎症指标[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、氧化应激反应指标[丙二醛(MDA)、超氧化物歧化酶(SOD)]及并发症。结果：研究组治疗后SaO2、PaO2、SOD水平均较对照组高，PaCO2、IL-6、TNF-α、MDA水平均较对照组低，差异均有统计学意义(P0.05)。结论：ARF患者采用NIPPV联合盐酸氨溴索灌洗治疗可改善血气分析指标，降低炎症指标与氧化应激反应指标水平，且安全性好。

    【关键词】 急性呼吸衰竭 无创正压通气 盐酸氨溴索 肺泡灌洗 血气分析 炎症指标

    Effect of Noninvasive Positive Pressure Ventilation Combined with Ambroxol Hydrochloride Perfusion on Blood Gas Analysis and Inflammatory Indexes in Patients with Acute Respiratory Failure/SHI Zhenyou， BAO Guohong. //Medical Innovation of China， 2024， 21(12)： 0-052

    [Abstract] Objective： To explore the effects of noninvasive positive pressure ventilation (NIPPV) combined with Ambroxol Hydrochloride perfusion on blood gas analysis and inflammation indexes in patients with acute respiratory failure (ARF). Method： A total of 94 ARF patients admitted to Yichun City Hospital of Traditional Chinese Medicine from April 2021 to March 2023 were selected and divided into a control group (47 patients) and a study group (47 patients) according to the method of randomized numerical table. The control group was treated with NIPPV ......