王玉洁 覃后继 易廷庄 黄嘉伟

    *基金项目：广西自然科学基金项目(2020GXNSFAA297170)；2020年百色市科学研究与技术开发计划-新冠肺炎病毒感染防治专项项目(百科20203215)

    【摘要】 非酒精性脂肪性肝病(non-alcoholic fatty liver disease，NAFLD)是一种以肝脏脂肪沉积为主的代谢性疾病，可导致肝脏脂肪变性、肝硬化及肝细胞肝癌(hepatocellular carcinoma，HCC)的发生发展。NAFLD与NAFLD相关HCC有着相似的多元化发病机制：胰岛素抵抗、脂肪代谢、遗传易感性、免疫失调、肠道菌群紊乱、铁沉积等。近些年随着NAFLD的患病率的增加，NAFLD相关HCC患病率也逐年增加，因此提早监测预防NAFLD相关HCC发生显得尤为重要。本文综述了NAFLD相关HCC的流行病学、发病机制、监测及预防，为认识NAFLD相关的HCC现状及预防奠定了基础。

    【关键词】 非酒精性脂肪性肝病 肝细胞肝癌 分子机制 疾病进展

    Research Progress of Non-alcoholic Fatty Liver Disease and Related Hepatocellular Carcinoma/WANG Yujie， QIN Houji， YI Tingzhuang， HUANG Jiawei. //Medical Innovation of China， 2024， 21(14)： -178

    [Abstract] Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease dominated by fat deposition in the liver， which can lead to the occurrence and development of hepatic steatosis， cirrhosis and hepatocellular carcinoma (HCC). NAFLD and NAFLD-related HCC share similar diversified pathogenesis， including insulin resistance， fat metabolism， genetic susceptibility， immune dysregulation， intestinal flora disorder， iron deposition ......