【摘要】 类风湿关节炎(rheumatoid arthritis，RA)是一种多关节慢性炎症性自身免疫性疾病，其发病机制主要包括炎症反应、软骨破坏及骨侵蚀和血管生成，并与炎症因子密切相关。其中白细胞介素-8(IL-8)为炎症因子中重要一员，故本文从炎症、软骨破坏及骨侵蚀和血管生成三方面对IL-8在RA发生发展中的作用机制展开综述。本文通过阐述IL-8与RA的相关性，明确IL-8在RA发病机制中的作用，以期为今后深入研究RA提供新的参考依据。

    【关键词】 类风湿关节炎 白细胞介素-8 趋化因子 炎症 骨破坏 血管翳

    Research Progress on the Relationship between Interleukin-8 and Rheumatoid Arthritis/WANG Zhendong， YANG Juanjuan， LI Haolin， JIN Fangmei， CHENG Weigang， WANG Haidong. //Medical Innovation of China， 2024， 21(16)： -188

    [Abstract] Rheumatoid arthritis (RA) is a polyarticular chronic inflammatory autoimmune disease， and its pathogenesis mainly includes inflammatory response， cartilage destruction and bone erosion and angiogenesis， which are closely related to inflammatory factors. Studies have shown that interleukin-8 (IL-8) is an important member of inflammatory factors， so this paper reviews the mechanism of IL-8 in the occurrence and development of RA from the three aspects of inflammation， cartilage destruction and bone erosion and angiogenesis. The paper clarifies the role of interleukin-8 in the pathogenesis of RA by describing the correlation between interleukin-8 and RA ......