【摘要】 目的：探究人工骨浆联合同种异体骨治疗对四肢骨缺损患者愈合情况及生活质量的影响。方法：选取102例于2021年5月—2023年12月在赣南医科大学第二附属医院进行治疗的四肢骨缺损患者作为研究对象，进行回顾性分析。根据治疗方式的不同将患者分为异体骨组(n=46，给予单纯同种异体骨治疗)、联合组(n=56，给予人工骨浆联合同种异体骨治疗)。比较两组愈合情况、愈合效果及生活质量。结果：联合组愈合时间早于异体骨组，差异有统计学意义(P<0.05)。两组并发症发生率比较，差异无统计学意义(P>0.05)。联合组和异体骨组术前VAS评分比较，差异无统计学意义(P>0.05)；联合组和异体骨组术后24 h VAS评分较术前均降低，且联合组术后24 h VAS评分低于异体骨组，差异均有统计学意义(P<0.05)。联合组术后3个月X射线评分高于异体骨组，差异有统计学意义(P<0.05)。联合组和异体骨组术前健康调查量表36(SF-36)评分比较，差异均无统计学意义(P>0.05)；联合组和异体骨组术后3个月SF-36评分均较术前升高，且联合组术后3个月SF-36评分均高于异体骨组，差异均有统计学意义(P<0.05)。结论：与单纯同种异体骨治疗相比，人工骨浆联合同种异体骨治疗四肢骨缺损，患者愈合时间短、术后疼痛感轻，有助于生活质量提高，且安全性高。

    【关键词】 人工骨浆 同种异体骨 四肢骨缺损 愈合效果 生活质量

    Effect of Artificial Bone Grafts Combined with Allogeneic Bone Therapy on the Healing Condition and Quality of Life of Patients with Limb Bone Defects/CHEN Jibing， QIU Miao， HU Fang. //Medical Innovation of China， 2024， 21(25)： 0-038

    [Abstract] Objective： To explore the effect of artificial bone grafts combined with allogeneic bone therapy on the healing condition and quality of life of patients with limb bone defects. Method： A total of 102 patients with limb bone defects who were treated in the Second Affiliated Hospital of Gannan Medical University from May 2021 to December 2023 were selected as the research objects and analyzed retrospectively. Patients were divided into allogeneic bone group (n=46 ......