【摘要】 光动力疗法(photodynamic therapy，PDT)是一种非侵入性、高选择性的肿瘤治疗方法，该方法利用适当波长的光激活光敏剂，产生瞬时水平的活性氧(reactive oxygen species，ROS)杀伤肿瘤细胞和肿瘤周围血管，以达到治疗效果。近年来，已有研究证实PDT不仅可以诱导肿瘤的局部免疫反应，而且对适应性免疫的建立也起到关键性作用。此外，最新的研究发现PDT联合免疫治疗具有协同增效作用。本文针对PDT诱导免疫应答的机制，以及目前PDT联合免疫治疗的相关基础研究和临床研究现状进行综述。

    【关键词】 光动力治疗 免疫调节 免疫治疗

    Research Progress of Photodynamic Therapy Combined with Immunotherapy in Malignant Tumors/TIAN Dan， XIA Siyu， LI Li. //Medical Innovation of China， 2024， 21(29)： -183

    [Abstract] Photodynamic therapy (PDT) is a non-invasive and highly selective tumor treatment that uses light of the appropriate wavelength to activate photosensitizer and produce instantaneous level reactive of oxygen species (ROS) to kill tumor cells and blood vessels around the tumor， thereby achieving therapeutic effects. In recent years， it has been confirmed that PDT can not only induce the local immune response of tumors， but also play a key role in the establishment of adaptive immunity. In addition， recent studies have found that PDT combined with immunotherapy has a synergistic effect. This article reviews the mechanism of immune response induced by PDT ......