猪肺磷脂注射液联合无创高频振荡通气对NRDS早产儿的影响



【摘要】 目的:探究猪肺磷脂注射液联合无创高频振荡通气(HFOV)对新生儿呼吸窘迫综合征(NRDS)早产儿肺表面活性蛋白A(SP-A)及肺循环功能的影响。方法:选取2022年3月—2024年2月江西省妇幼保健院新生儿科收治的120例NRDS早产儿,以随机数字表法分为对照组、观察组,各60例。在常规治疗基础上,对照组予以无创HFOV治疗,观察组予以猪肺磷脂注射液联合无创HFOV治疗。比较两组的疗效、治疗前后SP-A水平、肺循环功能指标[平均肺动脉压(MPAP)、肺血管阻力(PVR)、血管外肺水量(EVLW)]。结果:观察组总有效率高于对照组,差异有统计学意义(Plt;0.05)。治疗后,两组SP-A、MPAP、PVR、EVLW均低于治疗前,且观察组均低于对照组,差异均有统计学意义(Plt;0.05)。结论:猪肺磷脂注射液联合无创HFOV治疗NRDS早产儿,可提高疗效,降低患儿SP-A水平,改善肺循环功能,具有一定价值。
【关键词】 新生儿呼吸窘迫综合征 无创高频振荡通气 猪肺磷脂 肺表面活性蛋白A 肺循环功能
Effect of Poractant Alfa Injection Combined with Non-invasive High Frequency Oscillatory Ventilation on Premature Infants with NRDS/YAN Lili, WANG Haiyan, ZENG Xiaobo, ZHOU Jinlong. //Medical Innovation of China, 2024, 21(36): 0-025
[Abstract] Objective: To explore the effects of Poractant Alfa Injection combined with non-invasive high frequency oscillatory ventilation (HFOV) on pulmonary surfactant protein A (SP-A) and pulmonary circulatory function in premature infants with neonatal respiratory distress syndrome (NRDS). Method: A total of 120 premature infants with NRDS admitted to the Neonatology Department of Jiangxi Maternal and Child Health Hospital from March 2022 to February 2024 were selected and divided into control group and observation group by random number table method ......
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