【摘要】 肠道微生物群由多种微生物组成，包括双歧杆菌(Bifidobacteriales)、乳杆菌(Lactobacillus)等益生菌，参与维持肠道微环境的动态平衡、正常肠道功能及免疫炎症反应等过程。但在病理状态下，肠道微生物群的组成或丰度会发生变化，从而导致肠道功能的紊乱、各种疾病的发生等。肠道微生物群可通过介导机体炎症反应、免疫反应、特异性蛋白活化、产生某些致癌化合物等途径参与肿瘤的发生。胃肠道肿瘤是目前癌症死亡的主要原因之一，病例数量众多，病变部位广泛，现研究发现肠道微生物群紊乱与消化道肿瘤相关，故本文对近年来肠道微生物群与消化道肿瘤的相关研究做一综述。

    【关键词】 肠道微生物群 消化道肿瘤 食管癌 胃癌 胰腺癌

    Research Progress on the Relationship between Gut Microbiota and Gastrointestinal Tumors/WAN Lu， TONG Qiang， LIU Xiaobo. //Medical Innovation of China， 2025， 22(01)： -183

    [Abstract] The gut microbiota is composed of a variety of various microorganisms， including probiotics such as Bifidobacteriales and Lactobacillus， which participate in the process of maintaining the dynamic balance of the gut microenvironment， normal intestinal function， and immune inflammatory response. However， in the pathological state， the composition or abundance of gut microbiota will change， leading to intestinal dysfunction and the occurrence of various diseases. The gut microbiota can participate in the occurrence of tumors by mediating inflammation， immune response， specific protein activation and the production of some carcinogenic compounds. Gastrointestinal tumors is one of the main causes of cancer death at present ......