【摘要】 神经病理性疼痛是一种常见的以神经系统损伤或疾病为病理性基础的疼痛感受，其病因复杂，发病机制不明确，与神经损伤、炎症反应、免疫失调、代谢紊乱等密切相关。越来越多的研究发现，神经病理性疼痛的发生与自主神经系统的活动改变相关，在其临床症候群中往往伴随着各种各样自主神经功能紊乱的表现，探究自主神经系统参与神经病理性疼痛发病的作用机制有利于寻找新的治疗靶点。在本综述中，阐述了自主神经系统与疼痛传导通路之间的解剖学关联，总结了自主神经系统参与神经病理性疼痛的潜在的作用环节及其可能机制。

    【关键词】 自主神经 神经病理性疼痛 疼痛传导

    Research Advances of Autonomic Nervous System in the Regulation of Neuropathic Pain/JIANG Xiaohua， LIU Yabin， CHEN Guowu. //Medical Innovation of China， 2025， 22(01)： -188

    [Abstract] Neuropathic pain is a common pain sensation based on nervous system injury or disease. Its etiology is complex and its pathogenesis is unclear. It is closely related to nerve injury， inflammatory reaction， immune disorder and metabolic disorder. More and more studies have found that the occurrence of neuropathic pain is related to changes in the activity of autonomic nervous system， which is often accompanied by various manifestations of autonomic nervous system disorders in its clinical symptoms. Exploring the mechanism of autonomic nervous system's involvement in the pathogenesis of neuropathic pain is conducive to finding new therapeutic targets. In this review ......