【摘要】 目的：探讨甲巯咪唑联合振源胶囊对甲亢患者血清游离三碘甲状腺原氨酸(free triiodothyronine，FT3)、游离甲状腺素(free tetraiodothyronine，FT4)、促甲状腺激素(thyroid stimulating hormone，TSH)水平的影响。方法：回顾性选择2021年4月—2024年1月瑞金市人民医院收治的甲亢患者102例，根据治疗方法不同分为对照组49例和观察组53例。对照组患者采用甲巯咪唑治疗，观察组患者在对照组基础上联合振源胶囊进行治疗，均连续治疗3个月。对比两组患者的临床疗效、甲状腺功能、炎症因子、不良反应情况。结果：观察组患者总有效率(98.11%)高于对照组(83.67%)，差异有统计学意义(Plt;0.05)；治疗后，与对照组患者相比，观察组患者FT3、FT4、肿瘤坏死因子-α(tumor necrosis factor-α，TNF-α)、超敏C反应蛋白(hypersensitive C reactive protein，hs-CRP)和白细胞介素-6(interleukin-6，IL-6)水平均低，TSH水平高(Plt;0.05)；观察组患者总不良反应发生率(5.66%)低于对照组(18.37%)，差异有统计学意义(Plt;0.05)。结论：甲巯咪唑联合振源胶囊治疗甲亢可有效减轻患者的炎症反应，改善甲状腺功能，增强效果，安全性高。

    【关键词】 甲巯咪唑 振源胶囊 甲亢 甲状腺功能

    Effects of Thiamazole Combined with Zhenyuan Capsules on Serum FT3， FT4 and TSH Levels in Hyperthyroidism Patients/ZOU Junwen， HU Yuan， CHEN Yuanpeng. //Medical Innovation of China， 2025， 22(04)： 0-040

    [Abstract] Objective： To explore the effect of Thiamazole combined with Zhenyuan Capsules on serum free triiodothyronine (FT3)， free tetraiodothyronine (FT4) and thyroid stimulating hormone (TSH) levels in patients with hyperthyroidism. Method： A total of 102 patients with hyperthyroidism admitted to Ruijin People's Hospital from April 2021 to January 2024 were retrospectively selected and divided into the control group (n=49) and the observation group (n=53) according to different treatment methods. The control group was treated with Thiamazole treatment ......