【摘要】 目的：探讨内镜黏膜下剥离术(ESD)治疗消化系统癌前病变及癌症早期的临床效果。方法：回顾性选取吉安市中心人民医院2022年1月—2023年10月收治的82例消化系统癌前病变及癌症早期患者临床资料，按手术方法不同分为对照组与观察组，各41例。对照组行内镜下黏膜切除术(EMR)，观察组行ESD治疗。比较两组手术指标、病灶切除情况、应激水平、生活质量及并发症。结果：观察组手术时间长于对照组，术中出血量少于对照组，差异均有统计学意义(Plt;0.05)；观察组病灶完整切除率、侧切缘阴性率、垂直切缘阴性率均高于对照组，术后6个月生活质量各项评分均高于对照组，穿孔率高于对照组，差异均有统计学意义(Plt;0.05)。结论：ESD治疗消化系统癌前病变及癌症早期效果更佳，可提高病灶完整切除率，更好改善患者生活质量，但其操作难度大，术后穿孔风险高。

    【关键词】 消化系统 癌前病变 癌症早期 内镜黏膜下剥离术 内镜下黏膜切除术

    Clinical Efficacy of Endoscopic Submucosal Dissection in the Treatment of Precancerous Lesions and Early Stage Cancer of the Digestive System/LI Yi’an， ZHANG Wei. //Medical Innovation of China， 2025， 22(04)： 0-051

    [Abstract] Objective： To investigate the clinical efficacy of endoscopic submucosal dissection (ESD) in the treatment of precancerous lesions and early stage cancer of the digestive system. Method： Clinical data of 82 patients with precancerous lesions and early stage cancer of digestive system admitted to Ji’an Central People's Hospital from January 2022 to October 2023 were retrospectively selected. The patients were divided into a control group and an observation group according to different surgical methods ......