【摘要】 免疫球蛋白A肾病(IgA nephropathy，IgAN)是全球范围内最常见的原发性肾小球肾炎，以IgA为主的免疫球蛋白沉积在肾小球系膜区及毛细血管袢的一系列病理改变为特征。因其临床表现、病理特点在个体及种族之间表现各异，故需要为患者制定综合性、个体化的方案。近年来，随着对IgAN发病机制深入研究，在靶向治疗方面收获颇丰，本文简述IgAN发病机制，就目前IgAN治疗策略做一综述。

    【关键词】 IgA肾病 发病机制 治疗策略

    New Advances in the Pathogenesis and Treatment of IgA Nephropathy

    [Abstract] Immunoglobulin A nephropathy (IgA nephropathy， IgAN) is the most common primary glomerulonephritis worldwide， characterized by a series of pathological changes of immunoglobulin deposition in the mesangial area of the glomerulus and capillary loops where IgA is the main immunoglobulin. Due to the varying clinical manifestations and pathological characteristics among individuals and races， it is necessary to develop comprehensive and individualized plans for patients. In recent years， with in-depth research on the pathogenesis of IgAN， there have been significant gains in targeted therapy. This article briefly describes the pathogenesis of IgAN and provides a review of current IgAN treatment strategies.

    [Key words] IgA nephropathy Pathogenesis Therapeutic strategy

    IgA肾病(IgA nephropathy ......