【摘要】 细胞焦亡是一种炎症反应介导的程序性细胞死亡，其形态学和生化特征明显不同于其他形式的细胞死亡，与肝脏疾病的发生密切相关。基于此，本文将介绍细胞焦亡的发生机制，并阐述细胞焦亡在病毒性肝炎、肝纤维化、肝细胞癌、代谢相关脂肪性肝病中的发生发展作用，以期为临床肝病的预防及治疗提供新的思路和方法。

    【关键词】 细胞焦亡 肝纤维化 肝细胞癌

    Research Progress of Pyroptosis in Liver Diseases

    [Abstract] Pyroptosis is a kind of programmed cell death mediated by inflammatory response， its morphological and biochemical characteristics are obviously different from other forms of cell death， and it is closely related to the occurrence of liver diseases. Based on this， this paper will introduce the mechanism of pyroptosis， and explain the role of pyroptosis in the occurrence and development of viral hepatitis， liver fibrosis， hepatocellular carcinoma and metabolic associated fatty liver disease， in order to provide new ideas and methods for the prevention and treatment of clinical liver disease.

    [Key words] Pyrodeath Liver fibrosis Hepatocellular carcinoma

    焦亡是一种针对细胞内细菌的先天免疫防御，越来越多的证据表明，其也参与无菌炎症，如急性或慢性肝病。细胞焦亡作为一种非典型的程序性细胞死亡方式，若发生在肝癌细胞等异常细胞中，可加速其免疫应答以应对感染；但若发生在肝星状细胞(hepatic stellate cell，HSC)等正常细胞中，则易加剧炎症反应，导致细胞大量死亡、组织增生和器官功能衰竭等，因此细胞焦亡在肝脏疾病的发展过程中既有益也有弊 ......